Ranitidine
General
- Type: H2 Blocker
- Dosage Forms: 75, 150, 300
- Common Trade Names: Zantac
Adult Dosing
GERD: 150 mg PO BID
Pediatric Dosing
GERD: 5-10 mg/kg/day PO BID
Special Populations
- Pregnancy Rating: B
- Lactation: Probably Safe
- Renal Dosing
- Adult: CrCl < 50: 150 mg Qday; CrCl < 10: 75 -150 mg Qday; HD: give dose after dialysis
- Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
- Hepatic Dosing
- Adult: Not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Porphyria
- caution if hepatic impairment
- caution if renal impairment
- caution if chronic pulmonary disease
- caution if diabetes mellitus
- caution if immunocompromised
Adverse Reactions
Serious
- thrombocytopenia
- hepatotoxicity
- pneumonia
Common
- headache
- rash
- diarrhea
- myalgia
- xerostomia
- nausea/vomiting
- fatigue
Pharmacology
- Half-life: 2-3 hr, renal impairment: 5 hr
- Metabolism: liver
- Excretion: urine, feces
- Mechanism of Action: H2 blocker