Ranitidine: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* Porphyria | *Porphyria | ||
* | *Caution if impairment of liver or kidneys | ||
* | *Caution in chronic pulmonary disease | ||
*Caution if diabetes mellitus | |||
* | *Caution if immunocompromised | ||
* | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* | *Thrombocytopenia | ||
* | *Hepatotoxicity | ||
* | *[[Pneumonia]] | ||
===Common=== | ===Common=== | ||
* | *Nausea/vomiting/diarrhea | ||
* | *Fatigue | ||
* | *Headache | ||
* | *Rash | ||
* | *Myalgia | ||
*Xerostomia | |||
* | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: 2-3 hr, | *Half-life: 2-3 hr, Renal impairment: 5 hr | ||
*Metabolism: | *Metabolism: Liver | ||
*Excretion: | *Excretion: Urine, Feces | ||
*Mechanism of Action: H2 blocker | *Mechanism of Action: H2 blocker | ||
Revision as of 06:34, 4 April 2015
General
- Type: H2 Blocker
- Dosage Forms: 75, 150, 300
- Common Trade Names: Zantac
Adult Dosing
GERD: 150 mg PO BID
Pediatric Dosing
GERD: 5-10 mg/kg/day PO BID
Special Populations
- Pregnancy Rating: B
- Lactation: Probably Safe
- Renal Dosing
- Adult: CrCl < 50: 150 mg Qday; CrCl < 10: 75 -150 mg Qday; HD: give dose after dialysis
- Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
- Hepatic Dosing
- Adult: Not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Porphyria
- Caution if impairment of liver or kidneys
- Caution in chronic pulmonary disease
- Caution if diabetes mellitus
- Caution if immunocompromised
Adverse Reactions
Serious
- Thrombocytopenia
- Hepatotoxicity
- Pneumonia
Common
- Nausea/vomiting/diarrhea
- Fatigue
- Headache
- Rash
- Myalgia
- Xerostomia
Pharmacology
- Half-life: 2-3 hr, Renal impairment: 5 hr
- Metabolism: Liver
- Excretion: Urine, Feces
- Mechanism of Action: H2 blocker