Difference between revisions of "Ranitidine"

(Common)
Line 22: Line 22:
 
==Contraindications==
 
==Contraindications==
 
*Allergy to class/drug
 
*Allergy to class/drug
* Porphyria
+
*Porphyria
* caution if hepatic impairment
+
*Caution if impairment of liver or kidneys
* caution if renal impairment
+
*Caution in chronic pulmonary disease
* caution if chronic pulmonary disease
+
*Caution if diabetes mellitus
* caution if diabetes mellitus
+
*Caution if immunocompromised
* caution if immunocompromised
 
  
 
==Adverse Reactions==
 
==Adverse Reactions==
 
===Serious===
 
===Serious===
* thrombocytopenia
+
*Thrombocytopenia
*hepatotoxicity
+
*Hepatotoxicity
* pneumonia
+
*[[Pneumonia]]
  
 
===Common===
 
===Common===
* headache
+
*Nausea/vomiting/diarrhea
* rash
+
*Fatigue
* diarrhea
+
*Headache
* myalgia
+
*Rash
* xerostomia
+
*Myalgia
* nausea/vomiting
+
*Xerostomia
* fatigue
 
  
 
==Pharmacology==
 
==Pharmacology==
*Half-life: 2-3 hr, renal impairment: 5 hr
+
*Half-life: 2-3 hr, Renal impairment: 5 hr
*Metabolism: liver
+
*Metabolism: Liver
*Excretion: urine, feces
+
*Excretion: Urine, Feces
 
*Mechanism of Action: H2 blocker
 
*Mechanism of Action: H2 blocker
  

Revision as of 06:34, 4 April 2015

General

  • Type: H2 Blocker
  • Dosage Forms: 75, 150, 300
  • Common Trade Names: Zantac

Adult Dosing

GERD: 150 mg PO BID

Pediatric Dosing

GERD: 5-10 mg/kg/day PO BID

Special Populations

  • Pregnancy Rating: B
  • Lactation: Probably Safe
  • Renal Dosing
    • Adult: CrCl < 50: 150 mg Qday; CrCl < 10: 75 -150 mg Qday; HD: give dose after dialysis
    • Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
  • Hepatic Dosing
    • Adult: Not defined
    • Pediatric: not defined

Contraindications

  • Allergy to class/drug
  • Porphyria
  • Caution if impairment of liver or kidneys
  • Caution in chronic pulmonary disease
  • Caution if diabetes mellitus
  • Caution if immunocompromised

Adverse Reactions

Serious

Common

  • Nausea/vomiting/diarrhea
  • Fatigue
  • Headache
  • Rash
  • Myalgia
  • Xerostomia

Pharmacology

  • Half-life: 2-3 hr, Renal impairment: 5 hr
  • Metabolism: Liver
  • Excretion: Urine, Feces
  • Mechanism of Action: H2 blocker

See Also

Sources