Difference between revisions of "Ranitidine"

(Contraindications)
(Pharmacology)
Line 35: Line 35:
  
 
==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Half-life: 2-3 hr, renal impairment: 5 hr
*Metabolism:  
+
*Metabolism: liver
*Excretion:  
+
*Excretion: urine, feces
*Mechanism of Action:
+
*Mechanism of Action: H2 blocker
  
 
==See Also==
 
==See Also==

Revision as of 20:05, 28 March 2015

General

  • Type: H2 Blocker
  • Dosage Forms: 75, 150, 300
  • Common Trade Names: Zantac

Adult Dosing

GERD: 150 mg PO BID

Pediatric Dosing

GERD: 5-10 mg/kg/day PO BID

Special Populations

  • Pregnancy Rating: B
  • Lactation: Probably Safe
  • Renal Dosing
    • Adult: CrCl < 50: 150 mg Qday; CrCl < 10: 75 -150 mg Qday; HD: give dose after dialysis
    • Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
  • Hepatic Dosing
    • Adult: Not defined
    • Pediatric: not defined

Contraindications

  • Allergy to class/drug
  • Porphyria
  • caution if hepatic impairment
  • caution if renal impairment
  • caution if chronic pulmonary disease
  • caution if diabetes mellitus
  • caution if immunocompromised

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2-3 hr, renal impairment: 5 hr
  • Metabolism: liver
  • Excretion: urine, feces
  • Mechanism of Action: H2 blocker

See Also

Sources