Difference between revisions of "Ranitidine"

(Pediatric Dosing)
 
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==General==
 
==General==
*Type: H2 Blocker
+
*Type: [[H2 blocker]]
 
*Dosage Forms: 75, 150, 300
 
*Dosage Forms: 75, 150, 300
 
*Common Trade Names: Zantac
 
*Common Trade Names: Zantac
  
 
==Adult Dosing==
 
==Adult Dosing==
GERD: 150 mg PO BID
+
GERD: 150mg PO BID
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
GERD: 5-10 mg/kg/day PO BID
+
GERD: 5-10mg/kg/day PO BID
  
 
==Special Populations==
 
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*Lactation:
+
*Lactation: Probably Safe
 
*Renal Dosing
 
*Renal Dosing
**Adult
+
**Adult: CrCl < 50: 150mg Qday; CrCl < 10: 75 -150mg Qday; HD: give dose after dialysis
**Pediatric
+
**Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
 
*Hepatic Dosing
 
*Hepatic Dosing
**Adult
+
**Adult: Not defined
**Pediatric
+
**Pediatric: not defined
  
 
==Contraindications==
 
==Contraindications==
 
*Allergy to class/drug
 
*Allergy to class/drug
 +
*Porphyria
 +
*Caution if impairment of liver or kidneys
 +
*Caution in chronic pulmonary disease
 +
*Caution if diabetes mellitus
 +
*Caution if immunocompromised
  
 
==Adverse Reactions==
 
==Adverse Reactions==
 
===Serious===
 
===Serious===
 +
*Thrombocytopenia
 +
*Hepatotoxicity
 +
*[[Pneumonia]]
  
 
===Common===
 
===Common===
 +
*Nausea/vomiting/diarrhea
 +
*Fatigue
 +
*Headache
 +
*Rash
 +
*Myalgia
 +
*Xerostomia
  
 
==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Half-life: 2-3 hr, Renal impairment: 5 hr
*Metabolism:  
+
*Metabolism: Liver
*Excretion:  
+
*Excretion: Urine, Feces
*Mechanism of Action:
+
*Mechanism of Action: H2 blocker
  
 
==See Also==
 
==See Also==
  
==Sources==
 
  
 +
==References==
 
<references/>
 
<references/>
[[Category:Drugs]]
+
 
 +
[[Category:Pharmacology]]

Latest revision as of 06:41, 13 July 2017

General

  • Type: H2 blocker
  • Dosage Forms: 75, 150, 300
  • Common Trade Names: Zantac

Adult Dosing

GERD: 150mg PO BID

Pediatric Dosing

GERD: 5-10mg/kg/day PO BID

Special Populations

  • Pregnancy Rating: B
  • Lactation: Probably Safe
  • Renal Dosing
    • Adult: CrCl < 50: 150mg Qday; CrCl < 10: 75 -150mg Qday; HD: give dose after dialysis
    • Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
  • Hepatic Dosing
    • Adult: Not defined
    • Pediatric: not defined

Contraindications

  • Allergy to class/drug
  • Porphyria
  • Caution if impairment of liver or kidneys
  • Caution in chronic pulmonary disease
  • Caution if diabetes mellitus
  • Caution if immunocompromised

Adverse Reactions

Serious

Common

  • Nausea/vomiting/diarrhea
  • Fatigue
  • Headache
  • Rash
  • Myalgia
  • Xerostomia

Pharmacology

  • Half-life: 2-3 hr, Renal impairment: 5 hr
  • Metabolism: Liver
  • Excretion: Urine, Feces
  • Mechanism of Action: H2 blocker

See Also

References