Prothrombin complex concentrates: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: Hemostatics, blood components | ||
*Dosage Forms: | *Dosage Forms:lypophilized concentrate for reconstitution 500u/vial and 1000u/vial | ||
*Common Trade Names: | *Common Trade Names: Kcentra | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Based on pretreatment INR, units based on factor 9 content | |||
**INR2-<4: 25units/kg, not to exceed 2500 units | |||
**INR4-<6: 35units/kg, not to exceed 3500 units | |||
**INR>6: 50units/kg, not to exceed 5000 units | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Safety and efficacy not established | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: | *Lactation: Unknown, breast feeding not advised | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult-N/A | ||
**Pediatric | **Pediatric-N/A | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult-N/A | ||
**Pediatric | **Pediatric-N/A | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*DIC | |||
*known HIT (Heparin induced thrombocytopenia) | |||
===Serious=== | ===Serious=== | ||
*thromboembolism | |||
*blood product (hepatitis, HIV) | |||
===Common=== | ===Common=== | ||
*thromboembolic events (8.7%) | |||
*headache (7.8%) | |||
*hypotension (4.9%) | |||
*nausea/vomiting | |||
*arthralgia | |||
*ICH (2.9%) | |||
*mental status change (2.9%) | |||
*hypertension (2.9%) | |||
==Pharmacology== | ==Pharmacology== | ||
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==Sources== | ==Sources== | ||
Medscape | |||
<references/> | <references/> | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 13:44, 28 May 2015
General
- Type: Hemostatics, blood components
- Dosage Forms:lypophilized concentrate for reconstitution 500u/vial and 1000u/vial
- Common Trade Names: Kcentra
Adult Dosing
- Based on pretreatment INR, units based on factor 9 content
- INR2-<4: 25units/kg, not to exceed 2500 units
- INR4-<6: 35units/kg, not to exceed 3500 units
- INR>6: 50units/kg, not to exceed 5000 units
Pediatric Dosing
Safety and efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation: Unknown, breast feeding not advised
- Renal Dosing
- Adult-N/A
- Pediatric-N/A
- Hepatic Dosing
- Adult-N/A
- Pediatric-N/A
Contraindications
- Allergy to class/drug
- DIC
- known HIT (Heparin induced thrombocytopenia)
Serious
- thromboembolism
- blood product (hepatitis, HIV)
Common
- thromboembolic events (8.7%)
- headache (7.8%)
- hypotension (4.9%)
- nausea/vomiting
- arthralgia
- ICH (2.9%)
- mental status change (2.9%)
- hypertension (2.9%)
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
See Also
Sources
Medscape