Potassium iodide

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Administration

  • Type: Antidote, antithyroid agent
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Names: SSKI

Adult Dosing

  • Post radiation exposure, thyroid injury prophylaxis: 130mg PO daily
  • Induction of thyroid involution: 60-250mg PO TID for 10d prior to surgery

Pediatric Dosing

  • Post radiation exposure, thyroid injury prophylaxis:
  • <1mo: 16.25mg PO daily
  • 1mo-3y: 32.5mg PO daily
  • 3-12y: 65mg PO daily
  • >12yo, <68kg: 65mg PO daily
  • >12yo, >68kg: 130mg PO daily

Special Populations

Contraindications

  • Allergy to class/drug
  • Renal disorders
  • Iodide-induced goiter

Adverse Reactions

Serious

  • Goiter, hypothyroidism, thyroid adenoma
  • Hypersensitivity reaction

Common

  • Rash
  • GI irritation
  • Paresthesia

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion: Renal

Mechanism of Action

  • Protects the thyroid gland by blocking the uptake of radioactive isotopes of iodine

Comments

See Also

References

Authors:

Claire