Post-streptococcal glomerular nephritis: Difference between revisions
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*Streptozyme assay including ASO | *Streptozyme assay including ASO | ||
*Complement C3, C4, C50 | *Complement C3, C4, C50 | ||
* | *[[Urinalysis]] (dysmorphic red blood cells, varying degrees of proteinuria, red blood cell casts, and pyuria) | ||
==Management== | ==Management== | ||
*Supportive management (treat volume overload) | *Supportive management (treat volume overload) | ||
**Sodium and water restriction | **Sodium and water restriction | ||
** | **[[Furosemide]] (also controls hypertension) | ||
**Consider dialysis (for acute renal failure) | ***ACEi or CCBs for HTN not controlled by diuretics<ref>Geetha D et al. Poststreptococcal Glomerulonephritis Medication. eMedicine, Nov 2017. https://emedicine.medscape.com/article/240337-medication</ref> | ||
**Consider dialysis (for acute renal failure) | |||
==Disposition== | ==Disposition== | ||
Revision as of 02:46, 31 October 2018
Background
- Abbreviation: PSGN
- Most common cause of acute nephritis worldwide
- Risk greatest in children 5-12 years old and adults >60
- Caused by glomerular immune complex disease induced by specific nephritogenic strains of group A beta-hemolytic streptococcus (GAS)
Clinical Features
Most common:
- Edema
- Gross hematuria
- Hypertension
Varies from asymptomatic to microscopic hematuria to acute nephritic syndrome (gross hematuria, proteinuria, edema, hypertension, and acute kidney injury)
Typically diagnosed by acute nephritis + recent GAS infection (strep pharyngitis, impetigo)
Differential Diagnosis
Causes of Glomerulonephritis
- Poststreptococcal glomerulonephritis
- Hemolytic-uremic syndrome
- Henoch-Schonlein purpura
- IgA nephropathy
- Lupus nephritis
- Alport syndrome
- Goodpasture syndrome
- Paraneoplastic
Evaluation
- CBC
- Chem 7
- Streptozyme assay including ASO
- Complement C3, C4, C50
- Urinalysis (dysmorphic red blood cells, varying degrees of proteinuria, red blood cell casts, and pyuria)
Management
- Supportive management (treat volume overload)
- Sodium and water restriction
- Furosemide (also controls hypertension)
- ACEi or CCBs for HTN not controlled by diuretics[1]
- Consider dialysis (for acute renal failure)
Disposition
- Most have complete recovery, particularly children
- Resolution begins within the first two weeks
- Small subset have late renal complications (ie, hypertension, increasing proteinuria, and renal insufficiency)
See Also
References
- ↑ Geetha D et al. Poststreptococcal Glomerulonephritis Medication. eMedicine, Nov 2017. https://emedicine.medscape.com/article/240337-medication