Polyethylene glycol 3350

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Administration

  • Type: Laxatives, osmotic
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names: GaviLAX, GlycoLAX, MiraLax

Adult Dosing

  • Constipation, occasional
    • Oral: 17 g dissolved in 120-240 mL liquid

Pediatric Dosing

  • Constipation, occasional
    • Infants, Children, and Adolescents <17 years of age:
      • 0.2 to 0.8 g/kg/day though may be started at higher dose of 1 g/kg
      • Maximum daily dose of 17 g/day
  • Fecal impaction
    • Children and Adolescents
      • Oral: 1 to 1.5 g/kg daily for 3-6 days
        • Maximum daily dose of 100 g/day

Special Populations

Pregnancy Rating

  • Minimally absorbed, unlikely effect though not known

Lactation risk

  • Minimally absorbed

Renal Dosing

None

Hepatic Dosing

None

Contraindications

  • Allergy to class/drug
  • Bowel obstruction

Adverse Reactions

Serious

Common

  • Abdominal cramping
  • Bloating
  • Diarrhea

Pharmacology

  • Onset: 24 to 96 hours
  • Metabolism: none

Mechanism of Action

  • Osmotic agent that causes water retention in stool and increases stool frequency

Comments

  • Prolonged use may lead to electrolyte imbalance
  • Use with caution in those with renal impairment

See Also

References