Phentolamine: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: [[ | *Type: [[Alpha 1 Blocker]]; [[Antidote]], Extravasation; [[Antihypertensive]] | ||
*Routes of Administration: IV, IM | *Routes of Administration: IV, IM | ||
*Common Trade Names: OraVerse | *Common Trade Names: OraVerse | ||
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*Hypersensitivity to phentolamine or components | *Hypersensitivity to phentolamine or components | ||
*[[MI]] | *[[MI]] | ||
* | *CAD | ||
*Angina | *Angina | ||
*Caution if PUD | *Caution if PUD | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
*[[α antagonist]] | *[[alpha 1 Blocker|α antagonist]] | ||
==See Also== | |||
*[[Vasopressors]] | |||
==References== | ==References== | ||
<Epocrates, UpToDate> | <Epocrates, UpToDate> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Latest revision as of 10:38, 4 January 2022
Administration
- Type: Alpha 1 Blocker; Antidote, Extravasation; Antihypertensive
- Routes of Administration: IV, IM
- Common Trade Names: OraVerse
Adult Dosing
- Pheochromocytomectomy adjunct: 5mg IM/IV q2-4h PRN
- Start: 1-2h preop
- Extravasation (norepinephrine-associated): 5-10mg injected into affected area x1
- Start: within 12h of extravasation
- Hypertensive crisis: 5mg IM/IV q2-4h PRN
Pediatric Dosing
- Pheochromocytomectomy adjunct: 1mg IM/IV q2-4h PRN
- Start: 1-2h preop
Special Populations
- Pregnancy Risk Factor: C
Renal Dosing
- No dosing adjustments
Hepatic Dosing
- No dosing adjustments
Contraindications
- Hypersensitivity to phentolamine or components
- MI
- CAD
- Angina
- Caution if PUD
Adverse Reactions
Serious
- MI
- stroke
- hypotension, severe
- arrhythmias
- PUD
- priapism
Common
- tachycardia
- weakness
- dizziness
- flushing
- orthostatic hypotension
- nasal congestion
- nausea
- vomiting
- diarrhea
Pharmacology
- Half-life: 19 minutes
- Metabolism: Urine
- Excretion: CYP450
Mechanism of Action
See Also
References
<Epocrates, UpToDate>