Phenazopyridine

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Administration

  • Type: Genitourinary
  • Dosage Forms: 100, 200 mg
  • Routes of Administration: PO
  • Common Trade Names: Pyridium, Azo Urinary Pain Relief, Uricalm Max, Uristat

Adult Dosing

Dysuria

  • 100-200mg PO TID x 2 days

Pediatric Dosing

Dysuria

  • 6-12yo: 4mg/kg PO TID x 2 days
  • >12yo: 100-200mg PO TID x 2 days

Special Populations

  • Pregnancy Rating: B, contraindicated in pyelonephritis during pregnancy
  • Lactation risk: safety unknown, inadequate literature available; caution advised

Renal Dosing

  • Adult:
    • CrCl 50-80: give q12-16h
    • CrCl<50: contraindicated
  • Pediatric:
    • CrCl 50-80: give q12-16h
    • CrCl<50: contraindicated

Hepatic Dosing

  • Adult:
    • severe hepatitis: contraindicated
  • Pediatric:
    • severe hepatitis: contraindicated

Contraindications

  • Allergy to class/drug
  • glomerulonephritis
  • severe hepatitis
  • uremia
  • pyelonephritis during pregnancy
  • renal impairment

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: unknown
  • Metabolism: liver; CYP450
  • Excretion: urine (65% unchanged)
  • Mechanism of Action: produces topical analgesia

Comments

See Also

References