Phenazopyridine

Administration

• Type: Genitourinary
• Dosage Forms: 100, 200 mg
• Routes of Administration: PO
• Common Trade Names: Pyridium, Azo Urinary Pain Relief, Uricalm Max, Uristat

Adult Dosing

Dysuria

• 100-200mg PO TID x 2 days

Pediatric Dosing

Dysuria

• 6-12yo: 4mg/kg PO TID x 2 days
• >12yo: 100-200mg PO TID x 2 days

Special Populations

• Pregnancy Rating: B, contraindicated in pyelonephritis during pregnancy
• Lactation risk: safety unknown, inadequate literature available; caution advised

Renal Dosing

• Adult:
  • CrCl 50-80: give q12-16h
  • CrCl<50: contraindicated

• Pediatric:
  • CrCl 50-80: give q12-16h
  • CrCl<50: contraindicated

Hepatic Dosing

• Adult:
  • severe hepatitis: contraindicated

• Pediatric:
  • severe hepatitis: contraindicated

Contraindications

• Allergy to class/drug
• glomerulonephritis
• severe hepatitis
• uremia
• pyelonephritis during pregnancy
• renal impairment

Adverse Reactions

Serious

• anaphylactoid reaction
• Methemoglobinemia

Common

• urine discoloration
• rash
• pruritus
• nausea
• headache
• dyspepsia
• anemia
• anaphylaxis
• contact lens staining

Pharmacology

• Half-life: unknown
• Metabolism: liver; CYP450
• Excretion: urine (65% unchanged)
• Mechanism of Action: produces topical analgesia

See Also

• Dysuria
• Acute cystitis
• Abnormally colored urine