Penicillin G Benzathine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[ | ===[[Streptococcal pharyngitis]]=== | ||
*1.2 million units IM x 1 | *1.2 million units IM x 1 | ||
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==Special Populations== | ==Special Populations== | ||
*[[Drug | *[[Drug ratings in pregnancy|Pregnancy Rating]]: B | ||
*Lactation: Safe | *Lactation: Safe | ||
*Renal Dosing | *Renal Dosing | ||
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===Serious=== | ===Serious=== | ||
*[[Anaphylaxis]] | *[[Anaphylaxis]] | ||
*[[Hypersensitivity | *[[Hypersensitivity reaction]] | ||
*Exfoliative dermatitis | *Exfoliative dermatitis | ||
*[[Stevens Johnson Syndrome]] | *[[Stevens-Johnson syndrome and toxic epidermal necrolysis|Stevens Johnson Syndrome]] | ||
*Superinfection | *Superinfection | ||
*[[Clostridium | *[[Clostridium difficile]] | ||
*Jarisch-Herxheimer reaction | *Jarisch-Herxheimer reaction | ||
*Hemolytic anemia | *Hemolytic anemia | ||
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*Asthenia | *Asthenia | ||
*[[Headache]] | *[[Headache]] | ||
*[[Nausea and | *[[Nausea and vomiting]] | ||
*[[Diarrhea]] | *[[Diarrhea]] | ||
*Injection site reaction | *Injection site reaction | ||
*Sterile [[abscess]] | *Sterile [[Incision and drainage|abscess]] | ||
*Elevated creatinine | *Elevated creatinine | ||
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*[[Antibiotics (Main)]] | *[[Antibiotics (Main)]] | ||
== | ==References== | ||
<references/> | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 07:31, 23 February 2016
General
- Type: Penicillin, a type of Penicillin G
- Dosage Forms: IM
- Common Trade Names: Bicillin L-A
Adult Dosing
Streptococcal pharyngitis
- 1.2 million units IM x 1
Syphilis
- Primary, secondary, or latent <1yr
- 2.4 million units IM x 1
- Latent >1yr or unknown duration, or tertiary
- 2.4 million units IM qWeek x 3 weeks
- Neurosyphilis
- 4 million units IV Q4H x10 days
Rheumatic Fever Prophylaxis, Secondary
- 1.2 million units IM ever 4 weeks
Pediatric Dosing
Strep Pharyngitis
- <27kg: 0.6 million units IM x 1
- >27kg: 1.2 million units IM x 1
Syphilis
- Congenital (<1mo)
- 50,000 units/kg IM x 1
- Max: 2.4 million units/dose
- Info: For asymptomatic disease only
- Acquired
- Primary, secondary, or latent <1yr
- 50,000 units/kg IM x 1
- Max: 2.4 million units/dose
- Latent >1yr or unknown duration
- 50,000 units/kg IM qWeek x 3 weeks
- Max: 2.4 million units/dose
- Primary, secondary, or latent <1yr
Rheumatic Fever Prophylaxis, Secondary
- <27kg: 0.6 million units IM every 4 weeks
- >27kg: 1.2 million units IM every 4 weeks
Special Populations
- Pregnancy Rating: B
- Lactation: Safe
- Renal Dosing
- Adult
- CrCl 10-50: decrease dose 25%
- CrCl <10: decrease dose 50-80%
- Hemodialysis: give after dialysis without supplement
- Peritoneal Dialysis: decrease dose 50-80%
- Pediatric
- CrCl 10-50: decrease dose 25%
- CrCl <10: decrease dose 50-80%
- Hemodialysis: give supplement
- Adult
- Hepatic Dosing (Adult & Pediatric)
- No data
Black Box
- Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)
Contraindications
- Allergy to class/drug
- Anaphylactic reaction to Beta Lactams
Cautions
- Non-anaphylactic reaction to Beta Lactams
- Hypersensitivity to multiple compounds
- Asthma
- Recent antibiotic associated colitis
- Seizure disorder
- Renal imparement
Adverse Reactions
Serious
- Anaphylaxis
- Hypersensitivity reaction
- Exfoliative dermatitis
- Stevens Johnson Syndrome
- Superinfection
- Clostridium difficile
- Jarisch-Herxheimer reaction
- Hemolytic anemia
- Leukopenia
- Thrombocytopenia
- Nephrotoxicity
- Interstitial nephritis
- Seizures
- Neuropathy
Common
- Rash
- Urticaria
- Fever
- Puritis
- Fatigue
- Asthenia
- Headache
- Nausea and vomiting
- Diarrhea
- Injection site reaction
- Sterile abscess
- Elevated creatinine
Pharmacology
- Half-life: Unknown
- Metabolism: liver, CYP450
- Excretion: Urine
- Mechanism of Action: Bactericidal