Penicillin G Benzathine: Difference between revisions

 
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==Adult Dosing==
==Adult Dosing==
===[[Strep Pharyngitis]]===
===[[Streptococcal pharyngitis]]===
*1.2 million units IM x 1
*1.2 million units IM x 1


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*Latent >1yr or unknown duration, or tertiary
*Latent >1yr or unknown duration, or tertiary
**2.4 million units IM qWeek x 3 weeks
**2.4 million units IM qWeek x 3 weeks
*Neurosyphilis
**4 million units IV Q4H x10 days


===Rheumatic Fever Prophylaxis, Secondary===
===Rheumatic Fever Prophylaxis, Secondary===
*1.2 million units IM ever 4 weeks
*1.2 million units IM every 4 weeks


==Pediatric Dosing==
==Pediatric Dosing==
===[[Strep Pharyngitis]]===
*'''<27kg:''' 0.6 million units IM x 1
*'''>27kg:''' 1.2 million units IM x 1
===[[Syphilis]]===
*'''Congenital (<1mo)'''
**50,000 units/kg IM x 1
**Max: 2.4 million units/dose
**Info: For asymptomatic disease only
*'''Acquired'''
**Primary, secondary, or latent <1yr
***50,000 units/kg IM x 1
***Max: 2.4 million units/dose
**Latent >1yr or unknown duration
***50,000 units/kg IM qWeek x 3 weeks
***Max: 2.4 million units/dose
===Rheumatic Fever Prophylaxis, Secondary===
*'''<27kg:''' 0.6 million units IM every 4 weeks
*'''>27kg:''' 1.2 million units IM every 4 weeks


==Special Populations==
==Special Populations==
*Pregnancy:
*[[Drug ratings in pregnancy|Pregnancy Rating]]: B
*Lactation:
*Lactation: Safe
*Renal Dosing
*Renal Dosing
**Adult
**Adult
***CrCl 10-50: decrease dose 25%
***CrCl <10: decrease dose 50-80%
***Hemodialysis: give after dialysis without supplement
***Peritoneal Dialysis: decrease dose 50-80%
**Pediatric
**Pediatric
*Hepatic Dosing
***CrCl 10-50: decrease dose 25%
**Adult
***CrCl <10: decrease dose 50-80%
**Pediatric
***Hemodialysis: give supplement
*Hepatic Dosing (Adult & Pediatric)
**No data
 
==Black Box==
*Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)


==Contraindications==
==Contraindications==
*Allergy to class/drug
*Allergy to class/drug
*Anaphylactic reaction to [[Beta Lactams]]
===Cautions===
*Non-anaphylactic reaction to [[Beta Lactams]]
*Hypersensitivity to multiple compounds
*Asthma
*Recent antibiotic associated colitis
*[[Seizure]] disorder
*Renal imparement


==Adverse Reactions==
==Adverse Reactions==
===Serious===
===Serious===
*[[Anaphylaxis]]
*[[Hypersensitivity reaction]]
*Exfoliative dermatitis
*[[Stevens-Johnson syndrome and toxic epidermal necrolysis|Stevens Johnson Syndrome]]
*Superinfection
*[[Clostridium difficile]]
*Jarisch-Herxheimer reaction
*Hemolytic anemia
*Leukopenia
*[[Thrombocytopenia]]
*Nephrotoxicity
*Interstitial nephritis
*[[Seizures]]
*Neuropathy


===Common===
===Common===
*[[Rash]]
*Urticaria
*[[Fever]]
*Puritis
*Fatigue
*Asthenia
*[[Headache]]
*[[Nausea and vomiting]]
*[[Diarrhea]]
*Injection site reaction
*Sterile [[Incision and drainage|abscess]]
*Elevated creatinine


==Pharmacology==
==Pharmacology==
*Half-life:  
*Half-life: Unknown
*Metabolism:  
*Metabolism: liver, CYP450
*Excretion:  
*Excretion: Urine
*Mechanism of Action:
*Mechanism of Action: Bactericidal


==See Also==
==See Also==
Line 47: Line 113:
*[[Antibiotics (Main)]]
*[[Antibiotics (Main)]]


==Source==
==References==
<references/>


<references/>
[[Category:Pharmacology]]
[[Category:Drugs]]
[[Category:ID]]

Latest revision as of 21:05, 23 September 2019

General

Adult Dosing

Streptococcal pharyngitis

  • 1.2 million units IM x 1

Syphilis

  • Primary, secondary, or latent <1yr
    • 2.4 million units IM x 1
  • Latent >1yr or unknown duration, or tertiary
    • 2.4 million units IM qWeek x 3 weeks
  • Neurosyphilis
    • 4 million units IV Q4H x10 days

Rheumatic Fever Prophylaxis, Secondary

  • 1.2 million units IM every 4 weeks

Pediatric Dosing

Strep Pharyngitis

  • <27kg: 0.6 million units IM x 1
  • >27kg: 1.2 million units IM x 1

Syphilis

  • Congenital (<1mo)
    • 50,000 units/kg IM x 1
    • Max: 2.4 million units/dose
    • Info: For asymptomatic disease only
  • Acquired
    • Primary, secondary, or latent <1yr
      • 50,000 units/kg IM x 1
      • Max: 2.4 million units/dose
    • Latent >1yr or unknown duration
      • 50,000 units/kg IM qWeek x 3 weeks
      • Max: 2.4 million units/dose

Rheumatic Fever Prophylaxis, Secondary

  • <27kg: 0.6 million units IM every 4 weeks
  • >27kg: 1.2 million units IM every 4 weeks

Special Populations

  • Pregnancy Rating: B
  • Lactation: Safe
  • Renal Dosing
    • Adult
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give after dialysis without supplement
      • Peritoneal Dialysis: decrease dose 50-80%
    • Pediatric
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give supplement
  • Hepatic Dosing (Adult & Pediatric)
    • No data

Black Box

  • Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)

Contraindications

Cautions

  • Non-anaphylactic reaction to Beta Lactams
  • Hypersensitivity to multiple compounds
  • Asthma
  • Recent antibiotic associated colitis
  • Seizure disorder
  • Renal imparement

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: liver, CYP450
  • Excretion: Urine
  • Mechanism of Action: Bactericidal

See Also

References