Penicillin G Benzathine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[ | ===[[Streptococcal pharyngitis]]=== | ||
*1.2 million units IM x 1 | *1.2 million units IM x 1 | ||
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*Latent >1yr or unknown duration, or tertiary | *Latent >1yr or unknown duration, or tertiary | ||
**2.4 million units IM qWeek x 3 weeks | **2.4 million units IM qWeek x 3 weeks | ||
*Neurosyphilis | |||
**4 million units IV Q4H x10 days | |||
===Rheumatic Fever Prophylaxis, Secondary=== | ===Rheumatic Fever Prophylaxis, Secondary=== | ||
*1.2 million units IM | *1.2 million units IM every 4 weeks | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===[[Strep Pharyngitis]]=== | |||
*'''<27kg:''' 0.6 million units IM x 1 | |||
*'''>27kg:''' 1.2 million units IM x 1 | |||
===[[Syphilis]]=== | |||
*'''Congenital (<1mo)''' | |||
**50,000 units/kg IM x 1 | |||
**Max: 2.4 million units/dose | |||
**Info: For asymptomatic disease only | |||
*'''Acquired''' | |||
**Primary, secondary, or latent <1yr | |||
***50,000 units/kg IM x 1 | |||
***Max: 2.4 million units/dose | |||
**Latent >1yr or unknown duration | |||
***50,000 units/kg IM qWeek x 3 weeks | |||
***Max: 2.4 million units/dose | |||
===Rheumatic Fever Prophylaxis, Secondary=== | |||
*'''<27kg:''' 0.6 million units IM every 4 weeks | |||
*'''>27kg:''' 1.2 million units IM every 4 weeks | |||
==Special Populations== | ==Special Populations== | ||
*Pregnancy: | *[[Drug ratings in pregnancy|Pregnancy Rating]]: B | ||
*Lactation: | *Lactation: Safe | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
***CrCl 10-50: decrease dose 25% | |||
***CrCl <10: decrease dose 50-80% | |||
***Hemodialysis: give after dialysis without supplement | |||
***Peritoneal Dialysis: decrease dose 50-80% | |||
**Pediatric | **Pediatric | ||
*Hepatic Dosing | ***CrCl 10-50: decrease dose 25% | ||
** | ***CrCl <10: decrease dose 50-80% | ||
* | ***Hemodialysis: give supplement | ||
*Hepatic Dosing (Adult & Pediatric) | |||
**No data | |||
==Black Box== | |||
*Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest) | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Anaphylactic reaction to [[Beta Lactams]] | |||
===Cautions=== | |||
*Non-anaphylactic reaction to [[Beta Lactams]] | |||
*Hypersensitivity to multiple compounds | |||
*Asthma | |||
*Recent antibiotic associated colitis | |||
*[[Seizure]] disorder | |||
*Renal imparement | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Anaphylaxis]] | |||
*[[Hypersensitivity reaction]] | |||
*Exfoliative dermatitis | |||
*[[Stevens-Johnson syndrome and toxic epidermal necrolysis|Stevens Johnson Syndrome]] | |||
*Superinfection | |||
*[[Clostridium difficile]] | |||
*Jarisch-Herxheimer reaction | |||
*Hemolytic anemia | |||
*Leukopenia | |||
*[[Thrombocytopenia]] | |||
*Nephrotoxicity | |||
*Interstitial nephritis | |||
*[[Seizures]] | |||
*Neuropathy | |||
===Common=== | ===Common=== | ||
*[[Rash]] | |||
*Urticaria | |||
*[[Fever]] | |||
*Puritis | |||
*Fatigue | |||
*Asthenia | |||
*[[Headache]] | |||
*[[Nausea and vomiting]] | |||
*[[Diarrhea]] | |||
*Injection site reaction | |||
*Sterile [[Incision and drainage|abscess]] | |||
*Elevated creatinine | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: Unknown | ||
*Metabolism: | *Metabolism: liver, CYP450 | ||
*Excretion: | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: Bactericidal | ||
==See Also== | ==See Also== | ||
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*[[Antibiotics (Main)]] | *[[Antibiotics (Main)]] | ||
== | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | |||
[[Category: | [[Category:ID]] |
Latest revision as of 21:05, 23 September 2019
General
- Type: Penicillin, a type of Penicillin G
- Dosage Forms: IM
- Common Trade Names: Bicillin L-A
Adult Dosing
Streptococcal pharyngitis
- 1.2 million units IM x 1
Syphilis
- Primary, secondary, or latent <1yr
- 2.4 million units IM x 1
- Latent >1yr or unknown duration, or tertiary
- 2.4 million units IM qWeek x 3 weeks
- Neurosyphilis
- 4 million units IV Q4H x10 days
Rheumatic Fever Prophylaxis, Secondary
- 1.2 million units IM every 4 weeks
Pediatric Dosing
Strep Pharyngitis
- <27kg: 0.6 million units IM x 1
- >27kg: 1.2 million units IM x 1
Syphilis
- Congenital (<1mo)
- 50,000 units/kg IM x 1
- Max: 2.4 million units/dose
- Info: For asymptomatic disease only
- Acquired
- Primary, secondary, or latent <1yr
- 50,000 units/kg IM x 1
- Max: 2.4 million units/dose
- Latent >1yr or unknown duration
- 50,000 units/kg IM qWeek x 3 weeks
- Max: 2.4 million units/dose
- Primary, secondary, or latent <1yr
Rheumatic Fever Prophylaxis, Secondary
- <27kg: 0.6 million units IM every 4 weeks
- >27kg: 1.2 million units IM every 4 weeks
Special Populations
- Pregnancy Rating: B
- Lactation: Safe
- Renal Dosing
- Adult
- CrCl 10-50: decrease dose 25%
- CrCl <10: decrease dose 50-80%
- Hemodialysis: give after dialysis without supplement
- Peritoneal Dialysis: decrease dose 50-80%
- Pediatric
- CrCl 10-50: decrease dose 25%
- CrCl <10: decrease dose 50-80%
- Hemodialysis: give supplement
- Adult
- Hepatic Dosing (Adult & Pediatric)
- No data
Black Box
- Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)
Contraindications
- Allergy to class/drug
- Anaphylactic reaction to Beta Lactams
Cautions
- Non-anaphylactic reaction to Beta Lactams
- Hypersensitivity to multiple compounds
- Asthma
- Recent antibiotic associated colitis
- Seizure disorder
- Renal imparement
Adverse Reactions
Serious
- Anaphylaxis
- Hypersensitivity reaction
- Exfoliative dermatitis
- Stevens Johnson Syndrome
- Superinfection
- Clostridium difficile
- Jarisch-Herxheimer reaction
- Hemolytic anemia
- Leukopenia
- Thrombocytopenia
- Nephrotoxicity
- Interstitial nephritis
- Seizures
- Neuropathy
Common
- Rash
- Urticaria
- Fever
- Puritis
- Fatigue
- Asthenia
- Headache
- Nausea and vomiting
- Diarrhea
- Injection site reaction
- Sterile abscess
- Elevated creatinine
Pharmacology
- Half-life: Unknown
- Metabolism: liver, CYP450
- Excretion: Urine
- Mechanism of Action: Bactericidal