Difference between revisions of "Penicillin G Benzathine"

(Contraindications)
(Adverse Reactions)
Line 72: Line 72:
 
==Adverse Reactions==
 
==Adverse Reactions==
 
===Serious===
 
===Serious===
 +
*[[Anaphylaxis]]
 +
*[[Hypersensitivity Reaction]]
 +
*Exfoliative dermatitis
 +
*[[Steven-Johnson Syndrome]]
 +
 +
 +
  
 
===Common===
 
===Common===

Revision as of 12:53, 27 March 2014

General

Adult Dosing

Strep Pharyngitis

  • 1.2 million units IM x 1

Syphilis

  • Primary, secondary, or latent <1yr
    • 2.4 million units IM x 1
  • Latent >1yr or unknown duration, or tertiary
    • 2.4 million units IM qWeek x 3 weeks

Rheumatic Fever Prophylaxis, Secondary

  • 1.2 million units IM ever 4 weeks

Pediatric Dosing

Strep Pharyngitis

  • <27kg: 0.6 million units IM x 1
  • >27kg: 1.2 million units IM x 1

Syphilis

  • Congenital (<1mo)
    • 50,000 units/kg IM x 1
    • Max: 2.4 million units/dose
    • Info: For asymptomatic disease only
  • Acquired
    • Primary, secondary, or latent <1yr
      • 50,000 units/kg IM x 1
      • Max: 2.4 million units/dose
    • Latent >1yr or unknown duration
      • 50,000 units/kg IM qWeek x 3 weeks
      • Max: 2.4 million units/dose

Rheumatic Fever Prophylaxis, Secondary

  • <27kg: 0.6 million units IM every 4 weeks
  • >27kg: 1.2 million units IM every 4 weeks

Special Populations

  • Pregnancy: B
  • Lactation: Safe
  • Renal Dosing
    • Adult
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give after dialysis without supplement
      • Peritoneal Dialysis: decrease dose 50-80%
    • Pediatric
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give supplement
  • Hepatic Dosing (Adult & Pediatric)
    • No data

Black Box

  • Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)

Contraindications

Cautions

  • Non-anaphylactic reaction to Beta Lactams
  • Hypersensitivity to multiple compounds
  • Asthma
  • Recent antibiotic associated colitis
  • Seizure disorder
  • Renal imparement

Adverse Reactions

Serious



Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Source