Difference between revisions of "Penicillin G Benzathine"

(Special Populations)
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==Adult Dosing==
 
==Adult Dosing==
===[[Strep Pharyngitis]]===
+
===[[Streptococcal pharyngitis]]===
 
*1.2 million units IM x 1
 
*1.2 million units IM x 1
  
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*Latent >1yr or unknown duration, or tertiary
 
*Latent >1yr or unknown duration, or tertiary
 
**2.4 million units IM qWeek x 3 weeks
 
**2.4 million units IM qWeek x 3 weeks
 +
*Neurosyphilis
 +
**4 million units IV Q4H x10 days
  
 
===Rheumatic Fever Prophylaxis, Secondary===
 
===Rheumatic Fever Prophylaxis, Secondary===
*1.2 million units IM ever 4 weeks
+
*1.2 million units IM every 4 weeks
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
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==Special Populations==
 
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
+
*[[Drug ratings in pregnancy|Pregnancy Rating]]: B
 
*Lactation: Safe
 
*Lactation: Safe
 
*Renal Dosing
 
*Renal Dosing
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===Serious===
 
===Serious===
 
*[[Anaphylaxis]]
 
*[[Anaphylaxis]]
*[[Hypersensitivity Reaction]]
+
*[[Hypersensitivity reaction]]
 
*Exfoliative dermatitis
 
*Exfoliative dermatitis
*[[Stevens Johnson Syndrome]]
+
*[[Stevens-Johnson syndrome and toxic epidermal necrolysis|Stevens Johnson Syndrome]]
 
*Superinfection
 
*Superinfection
*[[Clostridium Difficile]]
+
*[[Clostridium difficile]]
 
*Jarisch-Herxheimer reaction
 
*Jarisch-Herxheimer reaction
 
*Hemolytic anemia
 
*Hemolytic anemia
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*Asthenia
 
*Asthenia
 
*[[Headache]]
 
*[[Headache]]
*[[Nausea and Vomiting]]
+
*[[Nausea and vomiting]]
 
*[[Diarrhea]]
 
*[[Diarrhea]]
 
*Injection site reaction
 
*Injection site reaction
*Sterile [[abscess]]
+
*Sterile [[Incision and drainage|abscess]]
 
*Elevated creatinine
 
*Elevated creatinine
  
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*[[Antibiotics (Main)]]
 
*[[Antibiotics (Main)]]
  
==Source==
+
==References==
 +
<references/>
  
<references/>
+
[[Category:Pharmacology]]
[[Category:Drugs]]
 

Revision as of 16:31, 7 January 2017

General

Adult Dosing

Streptococcal pharyngitis

  • 1.2 million units IM x 1

Syphilis

  • Primary, secondary, or latent <1yr
    • 2.4 million units IM x 1
  • Latent >1yr or unknown duration, or tertiary
    • 2.4 million units IM qWeek x 3 weeks
  • Neurosyphilis
    • 4 million units IV Q4H x10 days

Rheumatic Fever Prophylaxis, Secondary

  • 1.2 million units IM every 4 weeks

Pediatric Dosing

Strep Pharyngitis

  • <27kg: 0.6 million units IM x 1
  • >27kg: 1.2 million units IM x 1

Syphilis

  • Congenital (<1mo)
    • 50,000 units/kg IM x 1
    • Max: 2.4 million units/dose
    • Info: For asymptomatic disease only
  • Acquired
    • Primary, secondary, or latent <1yr
      • 50,000 units/kg IM x 1
      • Max: 2.4 million units/dose
    • Latent >1yr or unknown duration
      • 50,000 units/kg IM qWeek x 3 weeks
      • Max: 2.4 million units/dose

Rheumatic Fever Prophylaxis, Secondary

  • <27kg: 0.6 million units IM every 4 weeks
  • >27kg: 1.2 million units IM every 4 weeks

Special Populations

  • Pregnancy Rating: B
  • Lactation: Safe
  • Renal Dosing
    • Adult
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give after dialysis without supplement
      • Peritoneal Dialysis: decrease dose 50-80%
    • Pediatric
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give supplement
  • Hepatic Dosing (Adult & Pediatric)
    • No data

Black Box

  • Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)

Contraindications

Cautions

  • Non-anaphylactic reaction to Beta Lactams
  • Hypersensitivity to multiple compounds
  • Asthma
  • Recent antibiotic associated colitis
  • Seizure disorder
  • Renal imparement

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: liver, CYP450
  • Excretion: Urine
  • Mechanism of Action: Bactericidal

See Also

References