Paromomycin: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Intestinal [[amebiasis]]=== | ===Intestinal [[amebiasis]]=== | ||
*25- | *25-35mg/kg/day PO divided tid x5-10 days | ||
**Give with food | **Give with food | ||
===[[Hepatic encephalopathy]]=== | ===[[Hepatic encephalopathy]]=== | ||
*adjunct treatment: | *adjunct treatment: 1000mg PO QID x5-6 days | ||
**Give with food | **Give with food | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Intestinal [[amebiasis]]=== | ===Intestinal [[amebiasis]]=== | ||
*25- | *25-35mg/kg/day PO divided tid x5-10 days | ||
==Special Populations== | ==Special Populations== | ||
| Line 67: | Line 67: | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 21:03, 23 September 2019
Administration
- Type: Amebicide
- Dosage Forms: 250
- Routes of Administration: Oral
- Common Trade Names: Humatin
Adult Dosing
Intestinal amebiasis
- 25-35mg/kg/day PO divided tid x5-10 days
- Give with food
Hepatic encephalopathy
- adjunct treatment: 1000mg PO QID x5-6 days
- Give with food
Pediatric Dosing
Intestinal amebiasis
- 25-35mg/kg/day PO divided tid x5-10 days
Special Populations
- Poorly absorbed when given orally
- Use during pregnancy has limited data
Renal Dosing
- No change in dosing
Hepatic Dosing
- No change in dosing
Contraindications
- Allergy to class/drug
- GI obstruction
- caution if ulcerative colitis
- caution if inflammatory bowel disease
- caution if renal impairment
Adverse Reactions
Serious
- nephrotoxicity
- ototoxicity, auditory
- ototoxicity, vestibular
- neurotoxicity
- neuromuscular blockade
- malabsorption syndrome (prolonged use)
- superinfection (prolonged use)
- enterocolitis
Common
Pharmacology
- Half-life: Unknown
- Metabolism: CYP450
- Excretion: Feces
Mechanism of Action
Bactericidal and amebicidal. Paromomycin binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis; it suppresses urease producing bacteria, reducing ammonia absorption from gut
Comments
See Also
References
UpToDate, Epocrates