Opioid withdrawal: Difference between revisions
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#REDIRECT [[Opioid Withdrawl]]
==Background==
*Uncomfortable but not life-threatening
*Onset is 6-12hr after last heroin use, within 30hr after last methadone use
 
==Clinical Features==
#Onset: within hours of cessation
#Peak effects: 36-72hr
##Anxiety
##Craving
##Yawning
##Rhinorrhea
##Diaphoresis
#Onset: 12hr after cessation
#Peak effects: 72hr
##Tremor
##Piloerection
##Mydriasis
##Irritability
#Onset: 24-36hr after cessation
#Peak effects: 72hr
##Muscle spasm
##Abd pain
##N/V/D
 
==Treatment==
#Clonidine
##5mcg/kg PO (as long as SBP >90)
#Hydroxyzine
##50-100mg PO QID x5d
#Antiemetics
#Antidiarrheals
 
==Source==
*Tintinalli
 
[[Category:Tox]]

Revision as of 02:50, 5 January 2012

Background

  • Uncomfortable but not life-threatening
  • Onset is 6-12hr after last heroin use, within 30hr after last methadone use

Clinical Features

  1. Onset: within hours of cessation
  2. Peak effects: 36-72hr
    1. Anxiety
    2. Craving
    3. Yawning
    4. Rhinorrhea
    5. Diaphoresis
  3. Onset: 12hr after cessation
  4. Peak effects: 72hr
    1. Tremor
    2. Piloerection
    3. Mydriasis
    4. Irritability
  5. Onset: 24-36hr after cessation
  6. Peak effects: 72hr
    1. Muscle spasm
    2. Abd pain
    3. N/V/D

Treatment

  1. Clonidine
    1. 5mcg/kg PO (as long as SBP >90)
  2. Hydroxyzine
    1. 50-100mg PO QID x5d
  3. Antiemetics
  4. Antidiarrheals

Source

  • Tintinalli
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