Omeprazole

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Administration

  • Type: Proton pump inhibitor (PPI)
  • Dosage Forms: Tablets or capsules of 10, 20, 40, 80mg. Powder of omeprazole sodium for IV.
  • Routes of Administration: PO, IV
  • Common Trade Names: Prilosec

Adult Dosing

GERD

  • 20mg PO once daily, taken about 1 hour before meals

Peptic ulcers

  • 40mg PO daily

Zollinger Ellison syndrome

  • 60mg PO q8-24h

Pediatric Dosing

GERD

  • <1 year: Safety and efficacy not established
  • 5-10 kg: 5 mg PO qDay
  • 10-20 kg: 10 mg PO qDay
  • >20 kg: 20 mg PO qDay

Erosive Esophagitis

  • <1 month: Safety and efficacy not established
  • Aged 1 month to <1 year
    • 3 to <5 kg: 2.5 mg qDay
    • 5 to <10 kg: 5 mg qDay
    • ≥10 kg: 10 mg qDay
  • Aged 1-16 years
    • 5 to <10 kg: 5 mg PO qDay
    • 10 to <20 kg: 10 mg PO qDay
    • ≥20 kg: 20 mg PO qDay

Special Populations

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Not studied

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Agranulocytosis
  • Fractures, osteoporosis-related
  • Hepatotoxicity
  • Pancreatitis
  • Interstitial nephritis
  • Rhabdomyolysis

Common

  • Headache, dizziness
  • Nausea/vomiting, diarrhea, abdominal pain, flatulence, acid regurgitation, constipation
  • URI, cough
  • Rash
  • Gastric polyps
  • Alopecia
  • Atrophic gastritis

Pharmacology

  • Half-life: 1-1.2 hours [1]
  • Metabolism: Hepatic (CYP2C19, CYP3A4) [2]
  • Excretion: Urine

Mechanism of Action

  • PPI; binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in suppression of basal and stimulated acid secretion

Comments

See Also

References

  1. Prilosec Prescribing Information. AstraZeneca Pharmaceuticals.
  2. Prilosec Prescribing Information. AstraZeneca Pharmaceuticals.