Nystatin

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Administration

  • Type: Antifungal
  • Dosage Forms:
  • Routes of Administration:
    • PO
    • Topical
    • Vaginal
  • Common Trade Names: Nystop, Nyamyc

Adult Dosing

Candidiasis

  • Oral candidiasis
    • 4-6 mL PO QID of 100,000U/mL until 48 hrs after symptoms resolve
  • Intestinal candidiasis
    • 1-2 tabs (500,000 U) PO TID until 48 hrs after symptoms resolve

Pediatric Dosing

Oral candidiasis

  • Premature neonates:
    • 1 mL PO QID of 100,000 U/mL until 48 hrs after symptoms resolve
  • Infants:
    • 2 mL PO QID of 100,000 U/mL until 48 hrs after symptoms resolve
  • Children:
    • 4-6 mL PO QID of 100,000 U/mL until 48 hrs after symptoms resolve

Special Populations

Renal Dosing

  • Adult: not defined
  • Pediatric: not defined

Hepatic Dosing

  • Adult: not defined
  • Pediatric: not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Hypersensitivity reaction

Common

Pharmacology

  • Half-life: unknown
  • Metabolism: CYP450
  • Excretion: Feces

Mechanism of Action

  • Increases cell membrane permeability by binding to sterols

Comments

See Also

References