Nystatin

Administration

• Type: Antifungal
• Dosage Forms:
• Routes of Administration:
  • PO
  • Topical
  • Vaginal
• Common Trade Names: Nystop, Nyamyc

Adult Dosing

• Oral Candidiasis:
  • 4-6 mL PO QID of 100,000U/mL until 48 hrs after symptoms resolve
• Intestinal candidiasis
  • 1-2 tabs (500,000 U) PO TID until 48 hrs after symptoms resolve

Pediatric Dosing

• Oral candidiasis
  • Premature neonates:
    • 1 mL PO QID of 100,000 U/mL until 48 hrs after symptoms resolve
  • Infants:
    • 2 mL PO QID of 100,000 U/mL until 48 hrs after symptoms resolve
  • Children:
    • 4-6 mL PO QID of 100,000 U/mL until 48 hrs after symptoms resolve

Special Populations

• Pregnancy Rating: C
• Lactation risk: Safe

Renal Dosing

• Adult: not defined
• Pediatric: not defined

Hepatic Dosing

• Adult: not defined
• Pediatric: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Hypersensitivity rxn

Common

• Nausea / Vomiting
• Diarrhea
• Abdominal Pain

Pharmacology

• Half-life: unknown
• Metabolism: CYP450
• Excretion: Feces

Mechanism of Action

• Increases cell membrane permeability by binding to sterols

References

• Epocrates 2015