Nitazoxanide

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Administration

Adult Dosing

  • 500mg PO BID x 3 days

Pediatric Dosing

  • 1-3yo: 100mg BID x 3 days
  • 4-11yo: 200mg BID x 3 days
  • >11yo: 500mg BID x 3 days

Special Populations

  • Pregnancy Rating: B
  • Lactation risk: infant risk cannot be ruled out
  • Renal dosing:
  • Hepatic dosing:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

  • Abdominal pain, nausea
  • Headache
  • Abnormal color of urine

Pharmacology

  • Half-life: 1-1.6h
  • Metabolism:
  • Excretion: Mostly fecal

Mechanism of Action

  • inhibits pyruvate ferredoxin oxidoreductase, which is essential to anaerobic energy metabolism

Comments

See Also

References

Authors:

Claire