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Nifurtimox - Revision history
2024-03-29T04:41:33Z
Revision history for this page on the wiki
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https://wikem.org/w/index.php?title=Nifurtimox&diff=229545&oldid=prev
ClaireLewis: /* References */
2019-09-22T23:55:25Z
<p><span dir="auto"><span class="autocomment">References</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 23:55, 22 September 2019</td>
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ClaireLewis
https://wikem.org/w/index.php?title=Nifurtimox&diff=227793&oldid=prev
ClaireLewis: /* Comments */
2019-09-10T16:57:47Z
<p><span dir="auto"><span class="autocomment">Comments</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:57, 10 September 2019</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Comments==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Comments==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*Investigational status in the US<ref>https://reference.medscape.com/drug/lampit-nifurtimox-342663#0</ref></ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==See Also==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==See Also==</div></td></tr>
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ClaireLewis
https://wikem.org/w/index.php?title=Nifurtimox&diff=227790&oldid=prev
ClaireLewis: Created page with "==Administration== *Type: Antiparasitic *Dosage Forms: *Routes of Administration: PO *Common Trade Names: Lampit ==Adult Dosing== *8-10 mg/kg/day PO divided q6-8hr for 90..."
2019-09-10T16:54:33Z
<p>Created page with "==Administration== *Type: <a href="/wiki/Antiparasitic" title="Antiparasitic">Antiparasitic</a> *Dosage Forms: *Routes of Administration: PO *Common Trade Names: Lampit ==Adult Dosing== *8-10 mg/kg/day PO divided q6-8hr for 90..."</p>
<p><b>New page</b></p><div>==Administration==<br />
*Type: [[Antiparasitic]]<br />
*Dosage Forms:<br />
*Routes of Administration: PO<br />
*Common Trade Names: Lampit<br />
<br />
==Adult Dosing==<br />
*8-10 mg/kg/day PO divided q6-8hr for 90-120 days<br />
<br />
==Pediatric Dosing==<br />
*1-10 years: 15-20 mg/kg/day PO divided q8hr<br />
*11-16 years: 12.5-15 mg/kg/day PO divided q8hr x90 days<br />
<br />
==Special Populations==<br />
===[[Drug pregnancy categories|Pregnancy Rating]]===<br />
*Unknown risk, no human data available<br />
<br />
===Lactation risk===<br />
*Unknown<br />
<br />
===Renal Dosing===<br />
*Contraindicated in renal impairment<br />
<br />
===Hepatic Dosing===<br />
*Contraindicated in hepatic impairment<br />
<br />
==Contraindications==<br />
*Allergy to class/drug<br />
*Active or history of peripheral neuropathy<br />
*Active or history of seizures or cerebral impairment, behavioral disorders, or psychoses<br />
*Hepatic impairment<br />
*Renal impairment<br />
<br />
==Adverse Reactions==<br />
===Serious===<br />
*Seizures<br />
*Pleural effusion<br />
<br />
===Common===<br />
*Anorexia (can be significant and limit completion of therapy)<br />
*Ataxia, paresthesia, polyneuritis, tremor<br />
*Depression, fatigue, sleep disorder, weakness<br />
*Headache<br />
*Memory impairment<br />
*Rash, pruritic dermatitis<br />
*Gastralgia, vomiting<br />
*Myalgia<br />
*Pulmonary infiltrates<br />
<br />
==Pharmacology==<br />
*Half-life: 2.95 +/- 1.19 hr<br />
*Metabolism: Hepatic<br />
*Excretion: Urinary<br />
<br />
==Mechanism of Action==<br />
*Inhibits trypanothione reductase, a parasite-specific antioxidant defense enzyme<br />
<br />
==Comments==<br />
<br />
<br />
==See Also==<br />
*[[Chagas disease]]<br />
<br />
==References==<br />
<references/><br />
<br />
[[Category:Pharmacology]]</div>
ClaireLewis