Nifedipine

General

  • Type: Calcium Channel Blocker, Dihydropyridine
  • Dosage Forms: PO
  • Common Trade Names: Procardia, Nifediac, Nifedical, Adalat, Afeditab

Adult Dosing

Preterm labor/Tocolysis

  • 20mg x1, additional 20mg dose in 90min if ctx persist, followed by 20mg q3-8 hrs prn ctx

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • CHF
  • pulmonary edema
  • MI
  • arrhythmias
  • hypotension, severe
  • cholestasis
  • allergic hepatitis
  • angioedema
  • anaphylaxis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • toxic epidermal necrolysis
  • exanthematous pustulosis, acute generalized
  • GI obstruction (XL form)
  • GI ulcer (XL form)

Common

  • peripheral edema
  • headache
  • dizziness
  • flushing
  • fatigue/weakness
  • nausea
  • constipation
  • muscle cramps
  • nervousness
  • palpitations
  • dyspnea
  • nasal congestion
  • hypotension, transient
  • eczematous eruptions (chronic use, elderly pts)

Pharmacology

  • Half-life: 2h, 7h (ER)
  • Metabolism: liver, CYP450: 3A4 substrate
  • Excretion: urine 60-80% (<0.1% unchanged), bile/feces 20%
  • Mechanism of Action: inhibits calcium ion influx into vascular smooth muscle and myocardium

See Also

Sources