Nifedipine

General

• Type: Calcium Channel Blocker, Dihydropyridine
• Dosage Forms: PO
• Common Trade Names: Procardia, Nifediac, Nifedical, Adalat, Afeditab

Adult Dosing

Preterm labor/Tocolysis

• 20mg x1, additional 20mg dose in 90min if ctx persist, followed by 20mg q3-8 hrs prn ctx

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• CHF
• pulmonary edema
• MI
• arrhythmias
• hypotension, severe
• cholestasis
• allergic hepatitis
• angioedema
• anaphylaxis
• Stevens-Johnson syndrome
• exfoliative dermatitis
• toxic epidermal necrolysis
• exanthematous pustulosis, acute generalized
• GI obstruction (XL form)
• GI ulcer (XL form)

Pharmacology

• Half-life: 2h, 7h (ER)
• Metabolism: liver, CYP450: 3A4 substrate
• Excretion: urine 60-80% (<0.1% unchanged), bile/feces 20%
• Mechanism of Action: inhibits calcium ion influx into vascular smooth muscle and myocardium