Nifedipine: Difference between revisions
| Line 29: | Line 29: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 2h, 7h (ER) | ||
*Metabolism: | *Metabolism: liver, CYP450: 3A4 substrate | ||
*Excretion: | *Excretion: urine 60-80% (<0.1% unchanged), bile/feces 20% | ||
*Mechanism of Action: | *Mechanism of Action: inhibits calcium ion influx into vascular smooth muscle and myocardium | ||
==See Also== | ==See Also== | ||
Revision as of 22:52, 26 June 2015
General
- Type: Calcium Channel Blocker, Dihydropyridine
- Dosage Forms: PO
- Common Trade Names: Procardia, Nifediac, Nifedical, Adalat, Afeditab
Adult Dosing
Preterm labor/Tocolysis
- 20mg x1, additional 20mg dose in 90min if ctx persist, followed by 20mg q3-8 hrs prn ctx
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 2h, 7h (ER)
- Metabolism: liver, CYP450: 3A4 substrate
- Excretion: urine 60-80% (<0.1% unchanged), bile/feces 20%
- Mechanism of Action: inhibits calcium ion influx into vascular smooth muscle and myocardium