Nifedipine: Difference between revisions

Line 22: Line 22:
*Allergy to class/drug
*Allergy to class/drug
*galactose intolerance (lactose-containing forms)
*hypertensive crisis (IR form)
*HTN (IR form)
*caution if CHF
*caution if aortic stenosis
*caution if hypotension
*caution if renal impairment
*caution if hepatic impairment
*caution if anesthesia or surgery
*caution if concurrent or recent beta blocker use
*caution if GI stricture, severe (XL form)
*caution if GI hypomotility disorder (XL form)
*caution in elderly pts

==Adverse Reactions==
==Adverse Reactions==

Revision as of 22:58, 26 June 2015


  • Type: Calcium Channel Blocker, Dihydropyridine
  • Dosage Forms: PO
  • Common Trade Names: Procardia, Nifediac, Nifedical, Adalat, Afeditab

Adult Dosing

Preterm labor/Tocolysis

  • 20mg x1, additional 20mg dose in 90min if ctx persist, followed by 20mg q3-8 hrs prn ctx

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric


  • Allergy to class/drug
  • galactose intolerance (lactose-containing forms)
  • hypertensive crisis (IR form)
  • HTN (IR form)
  • caution if CHF
  • caution if aortic stenosis
  • caution if hypotension
  • caution if renal impairment
  • caution if hepatic impairment
  • caution if anesthesia or surgery
  • caution if concurrent or recent beta blocker use
  • caution if GI stricture, severe (XL form)
  • caution if GI hypomotility disorder (XL form)
  • caution in elderly pts

Adverse Reactions


  • CHF
  • pulmonary edema
  • MI
  • arrhythmias
  • hypotension, severe
  • cholestasis
  • allergic hepatitis
  • angioedema
  • anaphylaxis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • toxic epidermal necrolysis
  • exanthematous pustulosis, acute generalized
  • GI obstruction (XL form)
  • GI ulcer (XL form)


  • peripheral edema
  • headache
  • dizziness
  • flushing
  • fatigue/weakness
  • nausea
  • constipation
  • muscle cramps
  • nervousness
  • palpitations
  • dyspnea
  • nasal congestion
  • hypotension, transient
  • eczematous eruptions (chronic use, elderly pts)


  • Half-life: 2h, 7h (ER)
  • Metabolism: liver, CYP450: 3A4 substrate
  • Excretion: urine 60-80% (<0.1% unchanged), bile/feces 20%
  • Mechanism of Action: inhibits calcium ion influx into vascular smooth muscle and myocardium

See Also