Nifedipine: Difference between revisions

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==Adverse Reactions==
==Adverse Reactions==
*pulmonary edema
*hypotension, severe
*allergic hepatitis
*Stevens-Johnson syndrome
*exfoliative dermatitis
*toxic epidermal necrolysis
*exanthematous pustulosis, acute generalized
*GI obstruction (XL form)
*GI ulcer (XL form)


Revision as of 22:55, 26 June 2015


  • Type: Calcium Channel Blocker, Dihydropyridine
  • Dosage Forms: PO
  • Common Trade Names: Procardia, Nifediac, Nifedical, Adalat, Afeditab

Adult Dosing

Preterm labor/Tocolysis

  • 20mg x1, additional 20mg dose in 90min if ctx persist, followed by 20mg q3-8 hrs prn ctx

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric


  • Allergy to class/drug

Adverse Reactions


  • CHF
  • pulmonary edema
  • MI
  • arrhythmias
  • hypotension, severe
  • cholestasis
  • allergic hepatitis
  • angioedema
  • anaphylaxis
  • Stevens-Johnson syndrome
  • exfoliative dermatitis
  • toxic epidermal necrolysis
  • exanthematous pustulosis, acute generalized
  • GI obstruction (XL form)
  • GI ulcer (XL form)



  • Half-life: 2h, 7h (ER)
  • Metabolism: liver, CYP450: 3A4 substrate
  • Excretion: urine 60-80% (<0.1% unchanged), bile/feces 20%
  • Mechanism of Action: inhibits calcium ion influx into vascular smooth muscle and myocardium

See Also