Nicardipine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
'''Hypertension''' | |||
*PO: 20-40 mg q8hr, or 30-60mg (extended release) q12hr | |||
*IV: 5 mg/hr by slow infution (50 ml/hr) | |||
'''Chronic Stable Angina''' | |||
*20-40 mg PO q8hr | |||
*Allow 3 days between dose increase | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
'''Hypertension''' | |||
*0.5-3 mcg/kg/min IV | |||
*Not approved by FDA; limited date available | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: Category C | ||
*Lactation: | *Lactation: Unknown wether drug is excreted in breast milk; avoid use | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 2-4 hr | ||
*Metabolism: | *Metabolism: Metabolized in liver b CYP3A4 (first pass) | ||
*Excretion: | *Excretion: urine (60%), feces (35%) | ||
*Mechanism of Action: | *Mechanism of Action: | ||
Revision as of 05:58, 30 July 2015
General
- Type: Calcium Channel Blocker
- Dosage Forms: Capsule, Infusion solution, Injectable solution
- Common Trade Names: Cardene
Adult Dosing
Hypertension
- PO: 20-40 mg q8hr, or 30-60mg (extended release) q12hr
- IV: 5 mg/hr by slow infution (50 ml/hr)
Chronic Stable Angina
- 20-40 mg PO q8hr
- Allow 3 days between dose increase
Pediatric Dosing
Hypertension
- 0.5-3 mcg/kg/min IV
- Not approved by FDA; limited date available
Special Populations
- Pregnancy Rating: Category C
- Lactation: Unknown wether drug is excreted in breast milk; avoid use
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 2-4 hr
- Metabolism: Metabolized in liver b CYP3A4 (first pass)
- Excretion: urine (60%), feces (35%)
- Mechanism of Action: