Neuromuscular blocking agents: Difference between revisions
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!Side effects | !Side effects | ||
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| ''' | | '''Depolarizing''' | ||
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|[[Succinylcholine]] | |[[Succinylcholine]] | ||
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|fasciculations, post-operative pain | |fasciculations, post-operative pain | ||
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| '''Depolarizing''' | | '''Non-Depolarizing''' | ||
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|[[Vecuronium]] (Norcuron) | |[[Vecuronium]] (Norcuron) | ||
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*[[tachycardia]] (slight) | *[[tachycardia]] (slight) | ||
*(no hypotension) | *(no [[hypotension]]) | ||
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==See Also== | |||
*Reversal agent: [[Sugammadex]] | |||
==References== | ==References== | ||
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[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Critical Care]] | |||
Latest revision as of 00:47, 25 February 2020
Background
- Non-depolarizing
- Competitively block binding of ACh to its receptors
- Depolarizing
- Depolarizing skeletal muscle fiber
- Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh
Types
| Agent | Time to onset (seconds) | Duration (minutes) | Side effects |
|---|---|---|---|
| Depolarizing | |||
| Succinylcholine | fasciculations, post-operative pain | ||
| Non-Depolarizing | |||
| Vecuronium (Norcuron) | 60 | 30–40 | Few, may cause prolonged paralysis and promote muscarinic block |
| Rocuronium (Zemuron) | 75 | 45–70 | may promote muscarinic block |
| Pancuronium (Pavulon) | 90 | 180 or more |
|
See Also
- Reversal agent: Sugammadex