Neuromuscular blocking agents: Difference between revisions

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|+Neuromuscular Blocking Agents
|+Neuromuscular Blocking Agents
!Agent
!Agent
|'''Time to onset''' <br> (seconds)
!'''Time to onset''' (seconds)
|'''Duration''' <br> (minutes)
!'''Duration''' (minutes)
!Side effects
!Side effects
!Clinical use
|-
|-
| '''Non-Depolarizing'''
| '''Depolarizing'''
|-
|-
|[[Succinylcholine]]
|[[Succinylcholine]]
|
|
|
|
|
|fasciculations, post-operative pain  
|fasciculations, post-operative pain  
|-
|-
| '''Depolarizing'''
| '''Non-Depolarizing'''
|-
|[[Atracurium]] (Tracrium)
|90
|30 min or less<ref name=Rang151/>
|
*[[hypotension]], transiently,<ref name=Rang151/> by release of histamine
*Toxic metabolite called [[laudanosine]], greater accumulation in individuals with renal failure
|widely<ref name=Rang151/>
|-
|[[Cisatracurium]] (Nimbex)
|90
|60–80
|does not cause release of histamine
|
|-
|-
|[[Vecuronium]] (Norcuron)
|[[Vecuronium]] (Norcuron)
|60
|60
|30–40<ref name=Rang151/>
|30–40
|Few,<ref name=Rang151/> may cause prolonged paralysis<ref name=Rang151/> and promote muscarinic block
|Few, may cause prolonged paralysis and promote muscarinic block
|widely<ref name=Rang151/>
|-
|-
|[[Rocuronium]] (Zemuron)
|[[Rocuronium]] (Zemuron)
|75
|75
|45–70{{Citation needed|date=March 2010}}
|45–70
|may promote muscarinic block
|may promote muscarinic block
|
|-
|-
|[[Pancuronium]] (Pavulon)
|[[Pancuronium]] (Pavulon)
|90
|90
|180 or more{{Citation needed|date=March 2010}}
|180 or more
|
|
*[[tachycardia]] (slight)<ref name=Rang151/>
*[[tachycardia]] (slight)
(no hypotension)<ref name=Rang151/>
*(no [[hypotension]])
|widely<ref name=Rang151/>
|-
|-
|}
|}


==Sources==
==See Also==
*Reversal agent: [[Sugammadex]]
 
==References==
<references/>
<references/>
[[Category:Pharmacology]]
[[Category:Critical Care]]

Latest revision as of 00:47, 25 February 2020

Background

  • Non-depolarizing
    • Competitively block binding of ACh to its receptors
  • Depolarizing
    • Depolarizing skeletal muscle fiber
    • Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh

Types

Neuromuscular Blocking Agents
Agent Time to onset (seconds) Duration (minutes) Side effects
Depolarizing
Succinylcholine fasciculations, post-operative pain
Non-Depolarizing
Vecuronium (Norcuron) 60 30–40 Few, may cause prolonged paralysis and promote muscarinic block
Rocuronium (Zemuron) 75 45–70 may promote muscarinic block
Pancuronium (Pavulon) 90 180 or more

See Also

References

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