Neonatal conjunctivitis: Difference between revisions
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*Vesicles + conjunctivitis = full sepsis eval + acyclovir | *Vesicles + conjunctivitis = full sepsis eval + acyclovir | ||
== | ===Types=== | ||
====Chemical==== | |||
=== | |||
*Historically due to ocular prophylaxis with silver nitrate | *Historically due to ocular prophylaxis with silver nitrate | ||
*Occurs on 1st day of life | *Occurs on 1st day of life | ||
*Less common now with erythromycin ointment replacing silver nitrate | *Less common now with [[erythromycin]] ointment replacing [[silver nitrate]] | ||
===[[Gonococcal]]=== | ====[[Gonococcal]]==== | ||
*Peaks at 3-5 days after birth | *Peaks at 3-5 days after birth | ||
*Has potential to cause loss of vision | *Has potential to cause loss of vision | ||
*Hyperpurulent | *Hyperpurulent | ||
===[[Chlamydia]]=== | ====[[Chlamydia]]==== | ||
*Peaks from 1wk to 1 month after birth | *Peaks from 1wk to 1 month after birth | ||
*Leading cause of preventable blindness in the world | *Leading cause of preventable blindness in the world | ||
*May present with otitis and pneumonia with staccato cough | *May present with otitis and pneumonia with staccato cough | ||
===[[Herpes|Herpetic]]=== | |||
====[[Herpes|Herpetic]]==== | |||
*Peaks at 6-14 days of life | *Peaks at 6-14 days of life | ||
*May lead to keratitis and disseminated infection | *May lead to keratitis and disseminated infection | ||
===Streptococcus/S. Aureus=== | |||
====[[Streptococcus]]/[[S. Aureus]]==== | |||
*5 wks to 5 yrs | *5 wks to 5 yrs | ||
==Clinical Features== | |||
===[[Chlamydia]]=== | |||
*Can range from mild to severe hyperemia with thick mucopurulent discharge | |||
===[[Gonococcal]]=== | |||
*May present as typical conjunctivitis or with severe lid edema, cornea ulceration | |||
==Differential Diagnosis== | |||
{{Neonatal eye problems DDX}} | |||
==Diagnosis== | ==Diagnosis== |
Revision as of 16:04, 23 March 2016
Background
- Vesicles + conjunctivitis = full sepsis eval + acyclovir
Types
Chemical
- Historically due to ocular prophylaxis with silver nitrate
- Occurs on 1st day of life
- Less common now with erythromycin ointment replacing silver nitrate
Gonococcal
- Peaks at 3-5 days after birth
- Has potential to cause loss of vision
- Hyperpurulent
Chlamydia
- Peaks from 1wk to 1 month after birth
- Leading cause of preventable blindness in the world
- May present with otitis and pneumonia with staccato cough
Herpetic
- Peaks at 6-14 days of life
- May lead to keratitis and disseminated infection
Streptococcus/S. Aureus
- 5 wks to 5 yrs
Clinical Features
Chlamydia
- Can range from mild to severe hyperemia with thick mucopurulent discharge
Gonococcal
- May present as typical conjunctivitis or with severe lid edema, cornea ulceration
Differential Diagnosis
Neonatal eye problems
- Nasolacrimal duct obstruction
- Dacrocystitis
- Conjunctivitis
- Chemical
- Gonococcal
- Chlamydia
- Herpetic
- Streptococcus/S. Aureus
- Early onset glaucoma
- Uveitis
- Ocular foreign body
- Corneal abrasion
- Ocular trauma
- Ingrown eyelash
Diagnosis
- Gram stain/culture to r/o N. gonorrhea vs C. trachomatis
- C. trachomatis will have negative gram stain because it is an intracellular parasite.
Treatment
Prophylaxis
- Erythromycin 0.5% ointment x1 or tetracycline 1% or silver nitrate 1% x1 topical, applied at birth.
Chemical
- Watchful waiting
Gonococcal (onset 2-4 days)
- Cefotaxime 100mg/kg IV or IM OR ceftriaxone 25-50mg/kg IV or IM x1 (not to exceed 125mg)
- Cefotaxime is preferred because it does not displace bilirubin
- Disseminated disease should be suspected until CSF is negative
- Treat mother and partners
- Irrigate eyes with saline (topical antibiotics are insufficient and unnecessary)
Chlamydia (onset 5-10 days)
- Erythromycin ophthalmic ointment plus one of the following
- Azithromycin 20mg/kg PO once daily x 3 days OR
- Erythromycin 50mg/kg PO QD in 4 divided doses x 14 days
- Disease manifests 5 days post-birth to 2 weeks (late onset)
Herpetic (onset 6-14 days)
- Acyclovir 20mg/kg IV q8hr x 14-21d
- Topical antiviral
- Do not give steroids
- Full neonatal sepsis evaluation
- Immediate ophtho consult
Disposition
- Gonococcal
- Admit
- Herpetic
- Admit
See Also
Source
Tintinalli