Neonatal conjunctivitis: Difference between revisions

(Text replacement - "Category:Peds" to "Category:Pediatrics")
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*Vesicles + conjunctivitis = full sepsis eval + acyclovir
*Vesicles + conjunctivitis = full sepsis eval + acyclovir


==Clinical Features==
===Types===
===[[Chlamydia]]===
====Chemical====
*Can range from mild to severe hyperemia with thick mucopurulent discharge
===[[Gonococcal]]===
*May present as typical conjunctivitis or with severe lid edema, cornea ulceration
 
==Differential Diagnosis==
===Chemical===
*Historically due to ocular prophylaxis with silver nitrate
*Historically due to ocular prophylaxis with silver nitrate
*Occurs on 1st day of life
*Occurs on 1st day of life
*Less common now with erythromycin ointment replacing silver nitrate
*Less common now with [[erythromycin]] ointment replacing [[silver nitrate]]


===[[Gonococcal]]===
====[[Gonococcal]]====
*Peaks at 3-5 days after birth
*Peaks at 3-5 days after birth
*Has potential to cause loss of vision
*Has potential to cause loss of vision
*Hyperpurulent
*Hyperpurulent


===[[Chlamydia]]===
====[[Chlamydia]]====
*Peaks from 1wk to 1 month after birth
*Peaks from 1wk to 1 month after birth
*Leading cause of preventable blindness in the world
*Leading cause of preventable blindness in the world
*May present with otitis and pneumonia with staccato cough
*May present with otitis and pneumonia with staccato cough
===[[Herpes|Herpetic]]===
 
====[[Herpes|Herpetic]]====
*Peaks at 6-14 days of life
*Peaks at 6-14 days of life
*May lead to keratitis and disseminated infection
*May lead to keratitis and disseminated infection
===Streptococcus/S. Aureus===
 
====[[Streptococcus]]/[[S. Aureus]]====
*5 wks to 5 yrs
*5 wks to 5 yrs
==Clinical Features==
===[[Chlamydia]]===
*Can range from mild to severe hyperemia with thick mucopurulent discharge
===[[Gonococcal]]===
*May present as typical conjunctivitis or with severe lid edema, cornea ulceration
==Differential Diagnosis==
{{Neonatal eye problems DDX}}


==Diagnosis==
==Diagnosis==

Revision as of 16:04, 23 March 2016

Background

  • Vesicles + conjunctivitis = full sepsis eval + acyclovir

Types

Chemical

  • Historically due to ocular prophylaxis with silver nitrate
  • Occurs on 1st day of life
  • Less common now with erythromycin ointment replacing silver nitrate

Gonococcal

  • Peaks at 3-5 days after birth
  • Has potential to cause loss of vision
  • Hyperpurulent

Chlamydia

  • Peaks from 1wk to 1 month after birth
  • Leading cause of preventable blindness in the world
  • May present with otitis and pneumonia with staccato cough

Herpetic

  • Peaks at 6-14 days of life
  • May lead to keratitis and disseminated infection

Streptococcus/S. Aureus

  • 5 wks to 5 yrs

Clinical Features

Chlamydia

  • Can range from mild to severe hyperemia with thick mucopurulent discharge

Gonococcal

  • May present as typical conjunctivitis or with severe lid edema, cornea ulceration

Differential Diagnosis

Neonatal eye problems

Diagnosis

  • Gram stain/culture to r/o N. gonorrhea vs C. trachomatis
    • C. trachomatis will have negative gram stain because it is an intracellular parasite.

Treatment

Prophylaxis

Chemical

  • Watchful waiting

Gonococcal (onset 2-4 days)

  • Cefotaxime 100mg/kg IV or IM OR ceftriaxone 25-50mg/kg IV or IM x1 (not to exceed 125mg)
    • Cefotaxime is preferred because it does not displace bilirubin
    • Disseminated disease should be suspected until CSF is negative
    • Treat mother and partners
    • Irrigate eyes with saline (topical antibiotics are insufficient and unnecessary)

Chlamydia (onset 5-10 days)

  • Erythromycin ophthalmic ointment plus one of the following
  • Disease manifests 5 days post-birth to 2 weeks (late onset)

Herpetic (onset 6-14 days)

  • Acyclovir 20mg/kg IV q8hr x 14-21d
  • Topical antiviral
  • Do not give steroids
  • Full neonatal sepsis evaluation
  • Immediate ophtho consult

Disposition

  • Gonococcal
    • Admit
  • Herpetic
    • Admit

See Also

Source

Tintinalli