Mucormycosis

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Definition

Infection of fungal hyphae in immunocompromised hosts

-DM

-HIV

-Neutropenic


Pathophysiology

Most commonly affects paranasal sinuses (rhinocerebral mucormycosis)

Pulmonary

GI

CNS


Si/Sy

Rhinocerebral: mimics acute bacterial sinusitis, however a much more rapid, extensive expansion of the fungus to the surrounding anatomy is classic

Can spread to orbits, oropharynx, nasopharynx, brain, nearby vasculature leading to:

Vision changes

Nasopharyngeal and oropharyngeal ulceration or eschars

Facial edema, pain

Cranial nerve deficits

Headache


W/U

CT scan of sinuses


Treatment

Adjunctive: Amphotericin B (1mgkg/d IV)

Definitive: Prompt surgical consultation --> debridement


Prognosis

Mortality 30-90%