Difference between revisions of "Mucormycosis"

(Created page with "==Definition== Infection of fungal hyphae in immunocompromised hosts -DM -HIV -Neutropenic ==Pathophysiology== Most commonly affects paranasal sinuses (rhinocerebral m...")
 
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==Definition==
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==Background==
 
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#Infection of fungal hyphae in immunocompromised hosts
 
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##DM
Infection of fungal hyphae in immunocompromised hosts
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##HIV
 
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##Neutropenic
-DM
 
 
 
-HIV
 
 
 
-Neutropenic
 
 
 
 
 
 
==Pathophysiology==
 
 
 
 
 
Most commonly affects paranasal sinuses (rhinocerebral mucormycosis)
 
 
 
Pulmonary
 
 
 
GI
 
 
 
CNS
 
 
 
 
 
 
==Si/Sy==
 
  
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'''Locations'''
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#Most commonly affects paranasal sinuses (rhinocerebral mucormycosis)
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#Pulmonary
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#GI
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#CNS
  
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==Diagnosis==
 
Rhinocerebral: mimics acute bacterial sinusitis, however a much more rapid, extensive expansion of the fungus to the surrounding anatomy is classic
 
Rhinocerebral: mimics acute bacterial sinusitis, however a much more rapid, extensive expansion of the fungus to the surrounding anatomy is classic
  
 
Can spread to orbits, oropharynx, nasopharynx, brain, nearby vasculature leading to:
 
Can spread to orbits, oropharynx, nasopharynx, brain, nearby vasculature leading to:
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#Vision changes
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#Nasopharyngeal and oropharyngeal ulceration or eschars
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#Facial edema, pain
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#Cranial nerve deficits
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#Headache
  
Vision changes
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==Workup==
 
 
Nasopharyngeal and oropharyngeal ulceration or eschars
 
 
 
Facial edema, pain
 
 
 
Cranial nerve deficits
 
 
 
Headache
 
 
 
 
 
 
==W/U==
 
 
 
 
 
 
CT scan of sinuses
 
CT scan of sinuses
 
 
  
 
==Treatment==
 
==Treatment==
 
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#Adjunctive: Amphotericin B (1mgkg/d IV)
 
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#Definitive: Prompt surgical consultation --> debridement
Adjunctive: Amphotericin B (1mgkg/d IV)
 
 
 
Definitive: Prompt surgical consultation --> debridement
 
 
 
 
  
 
==Prognosis==
 
==Prognosis==
 
 
 
Mortality 30-90%
 
Mortality 30-90%
 
 
 
 
 
 
 
  
 
[[Category:ID]]
 
[[Category:ID]]

Revision as of 04:52, 28 March 2011

Background

  1. Infection of fungal hyphae in immunocompromised hosts
    1. DM
    2. HIV
    3. Neutropenic

Locations

  1. Most commonly affects paranasal sinuses (rhinocerebral mucormycosis)
  2. Pulmonary
  3. GI
  4. CNS

Diagnosis

Rhinocerebral: mimics acute bacterial sinusitis, however a much more rapid, extensive expansion of the fungus to the surrounding anatomy is classic

Can spread to orbits, oropharynx, nasopharynx, brain, nearby vasculature leading to:

  1. Vision changes
  2. Nasopharyngeal and oropharyngeal ulceration or eschars
  3. Facial edema, pain
  4. Cranial nerve deficits
  5. Headache

Workup

CT scan of sinuses

Treatment

  1. Adjunctive: Amphotericin B (1mgkg/d IV)
  2. Definitive: Prompt surgical consultation --> debridement

Prognosis

Mortality 30-90%