Difference between revisions of "Mold toxicity"

(Common Household Molds)
(Mechanism of Toxicity)
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*Allergy
 
*Allergy
 
**More commonly outdoor molds cause allergy but they can be found indoors in cases of excessive water damage
 
**More commonly outdoor molds cause allergy but they can be found indoors in cases of excessive water damage
*Infection
+
*[[Fungal infections|Infection]]
**Only a few fungi can infect immunocompetent people: Coccidioides, Blastomyces, Histoplasma, Cryptococcus
+
**Only a few fungi can infect immunocompetent people: [[Coccidioides]], [[Blastomyces]], [[Histoplasma]], [[Cryptococcus]]
**Immunocompromised people are at significant risk even from Candida and Aspergillus
+
**Immunocompromised people are at significant risk even from [[Candida]] and [[Aspergillus]]
 
*Toxicity
 
*Toxicity
 
**Glucans, a component of the cell wall, can produce Organic Dust Toxic Syndrome when inhaled
 
**Glucans, a component of the cell wall, can produce Organic Dust Toxic Syndrome when inhaled

Revision as of 04:11, 4 January 2017

Background

  • Molds are multicellular fungi that decompose organic matter

Common Household Molds

Mechanism of Toxicity

  • Allergy
    • More commonly outdoor molds cause allergy but they can be found indoors in cases of excessive water damage
  • Infection
  • Toxicity
    • Glucans, a component of the cell wall, can produce Organic Dust Toxic Syndrome when inhaled

Clinical Features

Mold Allergy

  • IgE antibodies against molds can lead to asthma or allergic rhinitis
  • Hypersensitivity pneumonitis is a rare immune response to high concentrations of fungal proteins

Organic Dust Toxic Syndrome

  • flu-like illness between 4-8 hours after heavy exposure to mold
  • Symptoms are self-limited and resolve in 24 hours

Sick Building Syndrome

  • Vague constellation of neurologic, dermatologic, gastrointestinal, and respiratory complaints attributed to a building's environment

Differential Diagnosis

Influenza-Like Illness

Evaluation

  • Generally, no specific workup in the ED
    • May workup specific symptoms, if deemed appropriate

Outpatient

Consider:

  • RAST (Radioallergosorbent) testing can detect IgE mediated allergy
  • Air samples and "bulk, wipe, and wall" samples can detect presence of molds

Management

  • No Specific drugs or antidotes
  • Decontamination and avoidance of environment

Disposition

  • Outpatient management

See Also

References