Methadone: Difference between revisions
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*QTc prolongation, torsades de pointes | |||
*respiratory depression/acidosis/arrest | |||
===Common=== | ===Common=== | ||
*constipation, nausea/vomiting, sedation, dizziness, hypotension | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 22:41, 10 July 2016
Administration
- Type: opioid
- Dosage Forms:
- Routes of Administration: oral, IM/subcutaneous
- Common Trade Names:
Adult Dosing
- varies widely due to patient variability in ADME, tolerance, indication
- Usual doses:
- Opioid use disorder, maintenance: 40-120mg/day
- Pain: initial dose 2.5mg TID for opioid naive
Pediatric Dosing
safety/efficacy not established in pediatric patients
- 0.1-0.2mg/kg q6h
Special Populations
- Pregnancy Rating: Class C
- Lactation risk: infant risk minimal
Renal Dosing
- Adult: lower initial starting dose
Hepatic Dosing
- Adult: lower initial starting dose
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- QTc prolongation, torsades de pointes
- respiratory depression/acidosis/arrest
Common
- constipation, nausea/vomiting, sedation, dizziness, hypotension
Pharmacology
- Half-life:
- Metabolism:
- Excretion: