Metal fume fever

Revision as of 15:12, 27 August 2019 by ClaireLewis (talk | contribs) (Clinical Features)


  • AKA brass founders' ague, brass shakes, zinc shakes, galvie flu, metal dust fever, Welding Shivers, Monday morning fever
  • Syndrome caused by inhalation of certain metals (most commonly zinc, copper, cadmium, but also aluminum, lead, nickel and various other metals[1]) in form of dust or fumes, usually through hot metalworking such as welding, brazing, smelting, or soldering.
  • Thought to be due to metals stimulating cytokine release

Clinical Features

Differential Diagnosis

Influenza-Like Illness


  • Clinical diagnosis, evaluate for alternate diagnoses
  • CXR and CT chest often unremarkable in milder cases but may show ground-glass opacities or other findings[2]
  • CBC- may have leukocytosis with neutrophil predominance[3]


  • Supportive
  • Most cases self-limiting within 24-48h


  • Discharge if clinically stable

See Also

External Links


  2. Kunimasa, Kei; Arita, Machiko; Tachibana, Hiromasa; Tsubouchi, Kazuya; Konishi, Satoshi; Korogi, Yohei; Nishiyama, Akihiro; Ishida, Tadashi (2011). "Chemical Pneumonitis and Acute Lung Injury Caused by Inhalation of Nickel Fumes". Internal Medicine. 50 (18): 2035–8.
  3. Kaye P, Young H, O'sullivan I. Metal fume fever: a case report and review of the literature. Emerg Med J. 2002;19(3):268-9.