Meclizine: Difference between revisions
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==General== | ==General== | ||
*Type: Antihistamine, H1 antagonist | *Type: [[Antihistamine]], H1 antagonist | ||
*Dosage Forms: 12.5, 25, | *Dosage Forms: 12.5, 25, 32mg oral tablet; 25mg oral chewable tablet | ||
*Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time | *Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time | ||
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===Motion Sickness=== | ===Motion Sickness=== | ||
*25- | *25-100mg PO 1 hour before activity. May repeat q24h | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*CNS depression | |||
*Caution in asthma, glaucoma, BPH, pyloric obstruction | |||
===Common=== | ===Common=== | ||
*Drowsiness, fatigue | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Onset: 1 hour | ||
*Metabolism: | *Half-life: 5 hours | ||
*Excretion: | *Metabolism: Hepatic | ||
*Mechanism of Action: | *Excretion: Urine and feces | ||
*Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways | |||
==See Also== | ==See Also== | ||
== | ==References== | ||
Lexicomp | |||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
Revision as of 08:35, 20 July 2016
General
- Type: Antihistamine, H1 antagonist
- Dosage Forms: 12.5, 25, 32mg oral tablet; 25mg oral chewable tablet
- Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time
Adult Dosing
Vertigo
- 25mg PO QID
Motion Sickness
- 25-100mg PO 1 hour before activity. May repeat q24h
Pediatric Dosing
- >= 12 yrs old: Adult dosing
- < 12 yrs: No dosing specified in drug insert
Special Populations
- Pregnancy Rating: B
- Lactation: Excretion in breast milk unknown
- Renal Dosing: n/a
- Hepatic Dosing: n/a
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- CNS depression
- Caution in asthma, glaucoma, BPH, pyloric obstruction
Common
- Drowsiness, fatigue
Pharmacology
- Onset: 1 hour
- Half-life: 5 hours
- Metabolism: Hepatic
- Excretion: Urine and feces
- Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways
See Also
References
Lexicomp