Lomotil toxicity

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  • Mixture of diphenoxylate/atropine used to treat diarrhea
  • Children are especially sensitive to toxicity (death reported after ingestion of <5 tablets)

Mechanism of toxicity

Clinical Features

Differential Diagnosis

Sedative/hypnotic toxicity

Anticholinergic toxicity Causes


  • Diagnosis is based on history and signs of toxicity



  • Pediatric patients should be observed in the ICU for 24 hours given risk of sudden respiratory arrest

See Also


  • Olson, K. Poisoning and Drug Overdose Clinical Manual. 2004
  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.