Lidocaine: Difference between revisions
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==General== | ==General== | ||
*Also known internationally as lignocaine | |||
*Type: [[Local anesthetics]]; [[Antiarrhythmics]] | *Type: [[Local anesthetics]]; [[Antiarrhythmics]] | ||
*Dosage Forms: | *Dosage Forms: Local injection, transdermal, intravenous, inhaled, viscous | ||
*Common Trade Names: | *Common Trade Names: Xylocaine, P-Care, ReadySharp Lidocaine, Xylocard <ref>Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019</ref> | ||
==Adult Dosing== | ==Adult Dosing== | ||
===[[Local anesthetics|Local Anesthetic]]=== | ===[[Local anesthetics|Local Anesthetic]]=== | ||
* | *Maximum without epinephrine: 5mg/kg (max 300mg) | ||
* | *Maximum with epinepherine: 7mg/kg (max 500mg) | ||
===[[Arrythmia|Antiarrhythmic]]=== | ===[[Arrythmia|Antiarrhythmic]]=== | ||
Line 28: | Line 29: | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: American B, Australia A | ||
*Lactation: | *Lactation: Not expected to cause any adverse effect <ref>https://www.ncbi.nlm.nih.gov/books/NBK501230/</ref> | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult: No adjustment provided in manufacturer's labelling but accumulation of metabolites may be increased in renal dysfunction<ref>Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019</ref> | ||
**Pediatric | **Pediatric: No adjustment provided in manufacturer's labelling <ref>Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019</ref> | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult: Reduce maintenance infusion when used IV (0.75 mg/minute). Monitor concentration.<ref>Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019</ref> | ||
**Pediatric | **Pediatric: Use with caution. Reduce dose. <ref>Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019</ref> | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to | *Allergy to amide anesthetics | ||
*High SA or AV block | **Note that these allergies are rare and are often caused by preservative, so a preservative-free formulation may be appropriate | ||
**Note that allergy to amide anesthetics does not suggest allergy to ester anesthetics | |||
*High SA or AV block (without pacemaker) | |||
*Concurrent treatment with Class I anti-dysrhythmic agents | |||
*[[Wolff-Parkinson-White syndrome]] | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Local=== | |||
*Dermatologic | |||
**Itching or irritation | |||
**Depigmentation | |||
**Rash/urticaria | |||
**Edema | |||
**Venous inflammation | |||
===Serious=== | ===Serious=== | ||
*[[Local Anesthetic Systemic Toxicity (LAST)]] | *[[Local Anesthetic Systemic Toxicity (LAST)]] | ||
**Rare during infiltration of local anesthetic | |||
**CNS toxicity | |||
***Metallic taste | |||
***Tinnitus | |||
***Tingling of lips | |||
***Dizziness | |||
***Anxiety | |||
***Confusion | |||
***Lethargy | |||
***Loss of consciousness | |||
***Seizures | |||
***Nausea/vomiting | |||
**Cardiovascular toxicity | |||
***Bradycardia | |||
***Decreased myocardial contractility | |||
***Atrioventricular block | |||
***Vasodilation | |||
***Ventricular arrhythmias | |||
***Cardiac arrest | |||
*Bronchospasm | |||
*Respiratory depression or arrest | |||
*Methemoglobinemia | |||
==Pharmacology== | ==Pharmacology== | ||
* | *Pharmacokinetics | ||
**Onset of action = 45-90s | **Onset of action = 45-90s | ||
**Duration of action = 10-20min (antiarrythmic IV); 30-90 min (subcutaneous) | **Duration of action = 10-20min (antiarrythmic IV); 30-90 min (subcutaneous) | ||
*Metabolism | **Half-life 90 - 120 minutes | ||
*Excretion | ***Prolonged in hepatic impairment or congestive heart failure | ||
*Mechanism of Action | *Metabolism | ||
**Primarily hepatic | |||
*Excretion | |||
**Urine | |||
*Mechanism of Action | |||
**Class Ib antiarrythmic | **Class Ib antiarrythmic | ||
***Binds to fast Na channels in inactive state thereby | ***Binds to fast Na channels in inactive state thereby raising the depolarization threshold | ||
***Acts preferentially on ischemic tissue | ***Acts preferentially on ischemic tissue | ||
****Elevates V-fib threshold | ****Elevates V-fib threshold | ||
****Suppresses ventricular ectopy | ****Suppresses ventricular ectopy | ||
**Little effect on vascular tone, contractility or cardiac output | **Little effect on vascular tone, contractility, or cardiac output | ||
==Comments== | ==Comments== | ||
* | *Mix lidocaine 1%/epinephrine with sodium bicarbonate 8.4% in 3:1 ratio results in significantly less painful injections. <ref>Vent A et. al Buffered lidocaine 1%/epinephrine 1:100,000 with sodium bicarbonate (sodium hydrogen carbonate) in a 3:1 ratio is less painful than a 9:1 ratio: A double-blind, randomized, placebo-controlled, crossover trial. J Am Acad Dermatol. 2020 Jul;83(1):159-165. doi: 10.1016/j.jaad.2019.09.088. https://pubmed.ncbi.nlm.nih.gov/31958526/ </ref> <ref>SGEM#307: Buff up the lido for the local anesthetic http://thesgem.com/2020/10/sgem307-buff-up-the-lido-for-the-local-anesthetic/</ref> | ||
*Inject through wound edges | **Shorter shelf-life due to decreased stability (use within 2 hours in the Vent A study) | ||
*Warming local anesthetics also decreases pain of injection <ref>Hogan, M., vanderVaart, S., Perampaladas, K., Machado, M., Einarson, T. and Taddio, A., 2020. Systematic Review And Meta-Analysis Of The Effect Of Warming Local Anesthetics On Injection Pain.</ref> | |||
*Inject through wound edges whenever possible | |||
**Avoid injecting through intact skin when possible | |||
==See Also== | ==See Also== | ||
Line 74: | Line 114: | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
Latest revision as of 09:22, 1 March 2024
See critical care quick reference for drug doses by weight.
General
- Also known internationally as lignocaine
- Type: Local anesthetics; Antiarrhythmics
- Dosage Forms: Local injection, transdermal, intravenous, inhaled, viscous
- Common Trade Names: Xylocaine, P-Care, ReadySharp Lidocaine, Xylocard [1]
Adult Dosing
Local Anesthetic
- Maximum without epinephrine: 5mg/kg (max 300mg)
- Maximum with epinepherine: 7mg/kg (max 500mg)
Antiarrhythmic
- Loading dose = 1-1.5mg/kg
- Additional boluses of 0.5-0.75mg/kg q5-10min up to max of 3mg/kg
- If effective start infusion of 2mg/min
- Indications
- Treatment of ventricular arrhythmias and ectopy
- Considered 2nd-line to amiodarone for treatment of V-fib and pulseless v-tach
- Treatment of ventricular arrhythmias and ectopy
Pediatric Dosing
Local Anesthetic
- Without epinepherine: 5mg/kg (max 300mg)
- With epinepherine: 7mg/kg (max 500mg)
Antiarrhythmic
See critical care quick reference for drug doses by weight.
Special Populations
- Pregnancy Rating: American B, Australia A
- Lactation: Not expected to cause any adverse effect [2]
- Renal Dosing
- Hepatic Dosing
Contraindications
- Allergy to amide anesthetics
- Note that these allergies are rare and are often caused by preservative, so a preservative-free formulation may be appropriate
- Note that allergy to amide anesthetics does not suggest allergy to ester anesthetics
- High SA or AV block (without pacemaker)
- Concurrent treatment with Class I anti-dysrhythmic agents
- Wolff-Parkinson-White syndrome
Adverse Reactions
Local
- Dermatologic
- Itching or irritation
- Depigmentation
- Rash/urticaria
- Edema
- Venous inflammation
Serious
- Local Anesthetic Systemic Toxicity (LAST)
- Rare during infiltration of local anesthetic
- CNS toxicity
- Metallic taste
- Tinnitus
- Tingling of lips
- Dizziness
- Anxiety
- Confusion
- Lethargy
- Loss of consciousness
- Seizures
- Nausea/vomiting
- Cardiovascular toxicity
- Bradycardia
- Decreased myocardial contractility
- Atrioventricular block
- Vasodilation
- Ventricular arrhythmias
- Cardiac arrest
- Bronchospasm
- Respiratory depression or arrest
- Methemoglobinemia
Pharmacology
- Pharmacokinetics
- Onset of action = 45-90s
- Duration of action = 10-20min (antiarrythmic IV); 30-90 min (subcutaneous)
- Half-life 90 - 120 minutes
- Prolonged in hepatic impairment or congestive heart failure
- Metabolism
- Primarily hepatic
- Excretion
- Urine
- Mechanism of Action
- Class Ib antiarrythmic
- Binds to fast Na channels in inactive state thereby raising the depolarization threshold
- Acts preferentially on ischemic tissue
- Elevates V-fib threshold
- Suppresses ventricular ectopy
- Little effect on vascular tone, contractility, or cardiac output
- Class Ib antiarrythmic
Comments
- Mix lidocaine 1%/epinephrine with sodium bicarbonate 8.4% in 3:1 ratio results in significantly less painful injections. [7] [8]
- Shorter shelf-life due to decreased stability (use within 2 hours in the Vent A study)
- Warming local anesthetics also decreases pain of injection [9]
- Inject through wound edges whenever possible
- Avoid injecting through intact skin when possible
See Also
References
- ↑ Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019
- ↑ https://www.ncbi.nlm.nih.gov/books/NBK501230/
- ↑ Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019
- ↑ Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019
- ↑ Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019
- ↑ Lidocaine. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. Accessed March 15, 2019
- ↑ Vent A et. al Buffered lidocaine 1%/epinephrine 1:100,000 with sodium bicarbonate (sodium hydrogen carbonate) in a 3:1 ratio is less painful than a 9:1 ratio: A double-blind, randomized, placebo-controlled, crossover trial. J Am Acad Dermatol. 2020 Jul;83(1):159-165. doi: 10.1016/j.jaad.2019.09.088. https://pubmed.ncbi.nlm.nih.gov/31958526/
- ↑ SGEM#307: Buff up the lido for the local anesthetic http://thesgem.com/2020/10/sgem307-buff-up-the-lido-for-the-local-anesthetic/
- ↑ Hogan, M., vanderVaart, S., Perampaladas, K., Machado, M., Einarson, T. and Taddio, A., 2020. Systematic Review And Meta-Analysis Of The Effect Of Warming Local Anesthetics On Injection Pain.