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Administration
- Type: Endocrine
- Dosage Forms:
- Routes of Administration: PO, IV
- Common Trade Names: Synthroid
Adult Dosing
Pediatric Dosing
Special Populations
Contraindications
- Allergy to class/drug, hypersensitivity to glycerol
- Uncorrected adrenal insufficiency (may precipitate acute adrenal crisis)
- Acute MI
- Subclinical or overt thyrotoxicosis, nontoxic diffuse goiter, nodular thyroid disease
Adverse Reactions
Serious
- MI, heart failure, tachycardia, cardiac arrest
- Pseudotumor, seizure
- Dyspnea
- Hyperthyroid
- Decreased bone mineral density, hip fracture
Common
- Palpitations
- Diarrhea
- Anxiety, insomnia, fatigue, sweating, weight loss
- Alopecia
Pharmacology
- Half-life: 6-7 days
- Metabolism: Hepatic
- Excretion: Renal, fecal
Mechanism of Action
- Synthetic thyroid hormone (T4)
See Also
References