Leukemia

Background

  • Hematologic malignancy that typically originates in bone marrow and results in high number of abnormal leukocytes or blasts

Types of Leukemia

Myeloid and Lymphoid lineage

Clinical Features

  • Varies by type

Complications

Differential Diagnosis

Leukocytosis

Workup Consideration

  • CXR
  • CBC with peripheral smear
  • Tumor lysis syndrome labs: chem7, ca, mg, phos, uric acid, UA, LDH
  • DIC labs: LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen
  • ESR, CRP
  • Reticulocyte count in anemia
  • Get extra purple top for flow cytometry, especially before transfusion

Management

  • Address any complications
  • Consult oncology for new diagnosis

See Also