Left ventricular assist device complications: Difference between revisions

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*Commonly referred to as an LVAD
*Commonly referred to as an LVAD
*Developed in 1960s as bridge to cardiac transplant
*Developed in 1960s as bridge to cardiac transplant
**LVAD (left ventricle), RVAD (right ventricle), BiVAD (both venticles via separate pumps)<ref name="LVAD Prehospital">Mechem CC. Prehospital assessment and management of patients with ventricular-assist devices. Prehosp Emerg Care. 2013 Apr-Jun;17(2):223-9.</ref>
*VADs have 3 major variables:
#Speed
#Flow
#Power
*Other parameters:
#Battery level - typically powered by two batteries, with power base unit that can be plugged into wall
#Pulsatility index:
#*Decreased index, may indicate low preload
#*Increased index, may indicate volume overload
#*Pump speed and pulsatility index are inversely related


==Applications==
==Applications==
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*Indication is New York Heart Association class 4 heart failure, ejection fraction <25%, VO2 max less than 15 among other criteria<ref>Mancini D, Lietz K. Selection of cardiac transplantation candidates in 2010. Circulation. 2010;122(2):173-83.</ref>
*Indication is New York Heart Association class 4 heart failure, ejection fraction <25%, VO2 max less than 15 among other criteria<ref>Mancini D, Lietz K. Selection of cardiac transplantation candidates in 2010. Circulation. 2010;122(2):173-83.</ref>
*Goal of a VAD is to assist the ventricle and augment cardiac output
*Goal of a VAD is to assist the ventricle and augment cardiac output
**LVAD (left ventricle), RVAD (right ventricle), BiVAD (both venticles via separate pumps)<ref name="LVAD Prehospital">Mechem CC. Prehospital assessment and management of patients with ventricular-assist devices. Prehosp Emerg Care. 2013 Apr-Jun;17(2):223-9.</ref>
*VADs have 3 major variables:
*#Speed
*#Flow
*#Power


===Components===
===Components===
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#'''Battery:''' 14V Li-Ion - 10 hrs
#'''Battery:''' 14V Li-Ion - 10 hrs
#'''Defib/Cardioversion:''' No precautions
#'''Defib/Cardioversion:''' No precautions
#'''Target INR:''' 1.8 to 2.5


====Thoratec VAD (HeartMate III)====
====Thoratec VAD (HeartMate III)====
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#'''Battery:''' 12V lead acid gel battery - 7.2 Ah - up to 3 hrs
#'''Battery:''' 12V lead acid gel battery - 7.2 Ah - up to 3 hrs
#'''Defib/Cardioversion:''' No precautions
#'''Defib/Cardioversion:''' No precautions
====HeartWare HVAD====
#'''Use:''' Bridge to Transplant
#'''Anatomy:''' Designed to be implanted completely in pericardial space, no need for pump pocket formation
#'''Flow Type:''' Centrifugal pump
#'''Target INR:''' 2.0-3.0


==Complications/Differential Diagnosis<ref name="LVAD" />==
==Complications/Differential Diagnosis<ref name="LVAD" />==
*Bleeding - most common reason for ED visit (frequency 42%<ref name="REMATCH">Rose EA, Gelijns AC, Moskowitz AJ et al. Long-term use of a left ventricular assist device for end-stage heart failure. N. Engl. J. Med. 2001; 345: 1435–1443.</ref>)
*Bleeding - most common reason for ED visit, most common in first month after implant (frequency 42%<ref name="REMATCH">Rose EA, Gelijns AC, Moskowitz AJ et al. Long-term use of a left ventricular assist device for end-stage heart failure. N. Engl. J. Med. 2001; 345: 1435–1443.</ref>)
**[[GI Bleed]], [[epistaxis]], [[ICH]], intrathoracic bleeding
**[[GI Bleed]], [[epistaxis]], [[ICH]], intrathoracic bleeding
**Mechanisms:
**Mechanisms:
***Acquired [[Von Willebrand Disease (vWD)]]
***Acquired [[Von Willebrand Disease (vWD)]] from pump shear forces<ref>Suarez J., Patel C.B., Felker G.M., Becker R., Hernandez A.F., Rogers J.G. Mechanisms of bleeding and approach to patients with axial-flow left ventricular assist devices. Circ Heart Fail. 2011;4:770–784.</ref>
***[[Coagulopathy (main)|supratherapeutic anticoagulation]]
***[[Coagulopathy (main)|supratherapeutic anticoagulation]]
***Lack of pulsatile flow → AV malformations in GI tract
***Lack of pulsatile flow → AV malformations in GI tract
***Passive hepatic congestion secondary to biventricular failure, predisoposing to bleeding
**Immediately consult VAD team/coordinator
**Immediately consult VAD team/coordinator
**Treatment - [[anticoagulant]] reversal based on specific agents used
**Treatment - [[anticoagulant]] reversal based on specific agents used
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*Infection - driveline and pocket are most common sites<ref name="REMATCH" />
*Infection - driveline and pocket are most common sites<ref name="REMATCH" />
**Usually [[gram positive bacteria]], but also need to cover for [[fungal infection]]
**Usually [[gram positive bacteria]], but also need to cover for [[fungal infection]]
*Pump Thrombosis
*Pump Thrombosis, estimated at 2-13%, average first thrombosis ~1 year after implant depending on device<ref>Nair N et al. Thrombolytics in VAD management — A single-center experience. Int J Cardiol Heart Vasc. 2016 Jun; 11: 49–54.</ref>
**Low output state with falsely elevated pump flow estimates on controller
**Low output state with falsely elevated pump flow estimates on controller
**Diagnose with echo or cardiac CTA
**Diagnose with echo or cardiac CTA
**Treatment with [[heparin]] and [[antiplatelet]] therapy
**Treatment with [[heparin]] and [[antiplatelet]] therapy
**Consider [[tPA]] in severe (life-threatening) situations
**Consider [[tPA]] in life-threatening situations
**Causes:
***Mechanical - post-surgical ventricular debris, cardiac emboli, inflow cannula malposition
***Inadequate anticoagulation and/or antiplatelet treatment
****As optimal dosing and monitoring not well defined due to lack of clinical trials
****Will occur despite rigid regimen and compliance of anticoagulation/antiplatelet
***Prosthetic material inflammatory reaction with blood
***Intrinsic endothelial activation in response to continuous flow-VAD
*[[Arrhythmia]] - very common
*[[Arrhythmia]] - very common
**Get labs to evaluate electrolytes and troponin
**Get labs to evaluate electrolytes and troponin
**Treatment [[atrial fibrillation]] as in any other patient
**Treat [[atrial fibrillation]] as in any other patient
**Treatment ventricular arrhythmias with volume replacement and pharmacological or electrical cardioversion
**Treat ventricular arrhythmias with volume replacement and pharmacological or electrical cardioversion
***Place pads anterior/posterior if going to cardiovert/defibrillate
***Place pads anterior/posterior if going to cardiovert/defibrillate
*"Suction event"
**Pump pulls from an LV that hasn't filled
**Causes:
***Cannula malposition
***Increased peripheral vascular resistance (hypertensive emergency)
***Tamponade


==Evaluation<ref name="LVAD">Partyka C, Taylor B. Review article: ventricular assist devices in the emergency department. Emerg Med Australas. 2014 Apr;26(2):104-12.</ref>==
==Evaluation<ref name="LVAD">Partyka C, Taylor B. Review article: ventricular assist devices in the emergency department. Emerg Med Australas. 2014 Apr;26(2):104-12.</ref>==
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**Demonstrates primary cardiac disease<ref name="LVAD 2">Pistono M, Corrà U, Gnemmi M, Imparato A, Temporelli PL, Tarro Genta F, Giannuzzi P. How to face emergencies in heart failure patients with ventricular assist device. Int J Cardiol. 2013 Oct 15;168(6):5143-8</ref>
**Demonstrates primary cardiac disease<ref name="LVAD 2">Pistono M, Corrà U, Gnemmi M, Imparato A, Temporelli PL, Tarro Genta F, Giannuzzi P. How to face emergencies in heart failure patients with ventricular assist device. Int J Cardiol. 2013 Oct 15;168(6):5143-8</ref>
**Generally, VAD does not influence underlying cardiac rhythm
**Generally, VAD does not influence underlying cardiac rhythm
*Bedside echo if able, formal echo if available
*Imaging:
**Bedside echo if able, formal echo if available, with the following suggestive of thrombosis:
***Cannula flow velocity > 2 m/s
***More frequent opening of aortic valve than at baseline
***Increasing LV internal dimension in diastole without manual speed changes
**CT with contrast to look for thrombus, discuss with radiologist to protocol
*Blood pressure measured with manual BP cuff and Doppler ultrasound - MAP is identified when constant flow is heard
*Blood pressure measured with manual BP cuff and Doppler ultrasound - MAP is identified when constant flow is heard
**MAP should be 70-90 mmHg
**MAP should be 70-90 mmHg
**Can also monitor with [[arterial line]]
**Can also monitor with [[arterial line]]
*Basic labs (CBC, CMP, Coags) should be obtained on all LVAD patients
*Basic lab should be obtained on all LVAD patients
*Cardiac labs - BNP, troponin
*Include thrombolysis, coagulopathy labs
**CBC
**CMP, indirect bilirubin
**PT/INT/PTT
**LDH
**Haptoglobin
**Fibrinogen
**UA, hematuria
**Quantitative plasma free hemoglobin
**Consider [[TEG]]
*LDH elevation over 1,150 IU/L suggestive of pump thrombosis<ref>Zoler ML. Cardiology News. STS: Lactate dehydrogenase of 1,150 IU/L flags LVAD thrombosis. https://www.mdedge.com/ecardiologynews/article/106621/heart-failure/sts-lactate-dehydrogenase-1150-iu/l-flags-lvad. Published Feb 19, 2016.</ref>
*LDH elevation over 1,150 IU/L suggestive of pump thrombosis<ref>Zoler ML. Cardiology News. STS: Lactate dehydrogenase of 1,150 IU/L flags LVAD thrombosis. https://www.mdedge.com/ecardiologynews/article/106621/heart-failure/sts-lactate-dehydrogenase-1150-iu/l-flags-lvad. Published Feb 19, 2016.</ref>
**Approximate sensitivity of ~80% and specificity of 90%
**Approximate sensitivity of ~80% and specificity of 90%
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==Management==
==Management==
*Immediately contact hospital or patient's LVAD coordinator to help coordinate care
*Immediately contact hospital or patient's LVAD coordinator to help coordinate care
*Check controller to ensure power light is on
**Ensure humming sound of pump is auscultated over chest/abdomen
**If pump not working, replace with patient's backup controller
**Check all connections to power source, driveline, and controller are intact
**Disconnect all connections after checking, and reconnect immediately
**Inspect driveline for damages/defects
*Assess battery, replace with backup battery
**Patient should be positioned flat on stretcher before replacing battery
**OR connect to hospital's power base unit or patient's power base unit if available
**IF NONE OF ABOVE, contact VAD coordinator to find local LVAD patient in vicinity willing to transport extra batteries to ED
**Take note that if battery is critically low, many devices will automatically lower speed, which can cause syncope or lightheadedness
*Hemodynamic, supportive care<ref>Troubleshooting the Left Ventricular Assist Device. Emergency Medicine. 2016 February;48(2):58-63.</ref>
**Many LVAD patients fluid restrict too much due to their history, and LVADs are preload dependent
**IVF crystalloid fluid bolus when indicated (low-flow indicator alarm)
**MAP goal 70-90 mmHg
*LVAD patients afterload sensitive
**Address high BP emergently if thought to contribute to increased work of pump, which leads to thrombus and stroke
**Beware of suction event complication, which requires IVF bolus and allowing the controller to sense this, slow pump speed and slowly bring up to fixed speed to allow for adequate ventricular filling
*Take special care to not twist, bend, cut, or otherwise damage the driveline
*Take special care to not twist, bend, cut, or otherwise damage the driveline
*First generation LVADs had pulsatile flow
*First generation LVADs had pulsatile flow
Line 108: Line 168:
*VADs are ECG independant, unlike ICD (many patients with a VAD will also have an ICD in place)
*VADs are ECG independant, unlike ICD (many patients with a VAD will also have an ICD in place)
**ICD discharges are common, and frequently inappropriate (possibly secondary to LVAD interference)<ref name="LVAD 2" />
**ICD discharges are common, and frequently inappropriate (possibly secondary to LVAD interference)<ref name="LVAD 2" />
*Ensure that patient or family bring in any additional batteries and charging elements as these will not be available in most hospital settings
*Thrombosis, [[tPA]] in emergencies
**Breadth of literature supporting is overall small
**When patient not responding to continuous anticoagulation ([[heparin]], [[argatroban]] drip)
**AND when going directly to LVAD exchange or catheter-directed thrombolysis are not possibilities
**Consider tPA if not contraindicated for survival and avoidance of needing LVAD exhange<ref>Nair N et al. Thrombolytics in VAD management — A single-center experience. Int J Cardiol Heart Vasc. 2016 Jun; 11: 49–54.</ref>
***5 mg IV bolus [[tPA]]
***3 mg/hr infusion in NS for 10 hours
***1 mg/hr for up to 48 hours, never exceeding 100 mg max total dosage
***In single center study cited above, there was:
****70% that had hemolysis resolve and no need for LVAD exchange at 30 days
****95% survival at 30 days
****10% hemorrhagic stroke with no difference between tPA and control group
**Alternative dosing, while plus/minus continuing heparin drip<ref>Webber BT et al. Intravenous thrombolytic therapy for patients with ventricular assist device thrombosis: An attempt to avoid reoperation. Ann Card Anaesth. 2016 Jan-Mar; 19(1): 192–196.</ref>
***Initial dosing of 10 mg IV bolus
***Followed by 1 mg/min for 20 min
***Then 1 mg/hr for 24 hours
***Monitor LDH levels and discontinue heparin drip when LDH acceptably lowered


===Cardiac Arrest<ref name="LVAD" />===
===Cardiac Arrest<ref name="LVAD" />===
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*'''Avoid chest compressions unless absolutely necessary''' - evaluate other causes of pump failure or lack of perfusion (e.g. pump thrombus) first
*'''Avoid chest compressions unless absolutely necessary''' - evaluate other causes of pump failure or lack of perfusion (e.g. pump thrombus) first
**Compressions can potentially damage LVAD, disrupt its connection to the heart (risk of exsanguination), etc
**Compressions can potentially damage LVAD, disrupt its connection to the heart (risk of exsanguination), etc
**Some studies available<ref>Shinar Z, Bellezzo J, Stahovich M, Cheskes S, Chillcott S, Dembitsky W. Chest compressions may be safe in arresting patients with left ventricular assist devices (LVADs). Resuscitation. 2014 May;85(5):702-4.</ref><ref>Mabvuure NT, Rodrigues JN. External cardiac compression during cardiopulmonary resuscitation of patients with left ventricular assist devices. Interact Cardiovasc Thorac Surg. 2014 Aug;19(2):286-9.</ref> indicate that CPR may not be as harmful as currently thought, or that abdominal compressions are an alternative<ref>Eric M Rottenberg, Jarrett Heard, Robert Hamlin, Benjamin C Sun, and Hamdy Awad. Abdominal only CPR during cardiac arrest for a patient with an LVAD during resternotomy: A case report. J Cardiothorac Surg. 2011; 6: 91.</ref> but further investigation needed
**Some studies available<ref>Shinar Z, Bellezzo J, Stahovich M, Cheskes S, Chillcott S, Dembitsky W. Chest compressions may be safe in arresting patients with left ventricular assist devices (LVADs). Resuscitation. 2014 May;85(5):702-4.</ref><ref>Mabvuure NT, Rodrigues JN. External cardiac compression during cardiopulmonary resuscitation of patients with left ventricular assist devices. Interact Cardiovasc Thorac Surg. 2014 Aug;19(2):286-9.</ref> indicate that CPR may not be as harmful as previously thought, or that abdominal compressions are an alternative<ref>Eric M Rottenberg, Jarrett Heard, Robert Hamlin, Benjamin C Sun, and Hamdy Awad. Abdominal only CPR during cardiac arrest for a patient with an LVAD during resternotomy: A case report. J Cardiothorac Surg. 2011; 6: 91.</ref> but further investigation needed
**Use clinical judgement for initiation of compressions
**Use clinical judgement for initiation of compressions


==Disposition==
==Disposition==
*Immediately contact the patient's VAD coordinator
*Immediately contact the patient's VAD coordinator
*Almost all LVAD patient presenting to the ED will require admission
*Almost all LVAD patient presenting to the ED will require admission or transfer to a site of expertise


==See Also==
==See Also==
Line 130: Line 208:
*[http://marylandccproject.org/2013/12/12/introduction-ventricular-assist-devices/ VAD Review]
*[http://marylandccproject.org/2013/12/12/introduction-ventricular-assist-devices/ VAD Review]
*[http://emcrit.org/wee/left-ventricular-assist-devices-lvads/ EMCrit LVAD Management]
*[http://emcrit.org/wee/left-ventricular-assist-devices-lvads/ EMCrit LVAD Management]
*[http://www.mylvad.com/sites/mylvadrp/files/Field%20Guides%20Master%20Document.pdf Mechanical Circulatory Support Organization EMS Guide]
*[http://www.mylvad.com MyLVAD] OR [http://www.mylvad.com/sites/mylvadrp/files/Field%20Guides%20Master%20Document.pdf Mechanical Circulatory Support Organization EMS Guide]


==References==
==References==

Revision as of 17:11, 28 April 2019

Background

  • Commonly referred to as an LVAD
  • Developed in 1960s as bridge to cardiac transplant
    • LVAD (left ventricle), RVAD (right ventricle), BiVAD (both venticles via separate pumps)[1]
  • VADs have 3 major variables:
  1. Speed
  2. Flow
  3. Power
  • Other parameters:
  1. Battery level - typically powered by two batteries, with power base unit that can be plugged into wall
  2. Pulsatility index:
    • Decreased index, may indicate low preload
    • Increased index, may indicate volume overload
    • Pump speed and pulsatility index are inversely related

Applications

  • Modern applications have expanded beyond original purpose:
    • Bridge to cardiac transplant
    • Temporizing measure for cardiomyopathies that are expected to resolve
    • Destination therapy for patients who will not undergo cardiac transplant
  • Indication is New York Heart Association class 4 heart failure, ejection fraction <25%, VO2 max less than 15 among other criteria[2]
  • Goal of a VAD is to assist the ventricle and augment cardiac output

Components

  • Pump = Internal pump (usually placed in preperitoneal space), takes blood from a cannula in the apex of the left ventricle and pumps it into the aorta
  • Driveline = Percutaneous cable that exits the abdominal wall, connects pump to external components (controller, battery)
  • Controller = External "box" containing computer for the device that monitors pump performance, has a display screen and controls for settings/alarms/diagnostics, and will display will show pump speed in RPM and pump output in L/min
  • Power Supply = Controller can be connected to batteries for patient mobility, or to a "power base station" that plugs into the wall for home use

Devices Overview

Heartmate I
Heartmate II
Thoratec-VAD

HeartMate I or XVE

  1. Use: Destination Therapy
  2. Flow Type: Pulsatile
  3. Backup Method: Hand Pump
  4. Battery: 12volt MiMH - 10hrs
  5. Defib/Cardioversion: Use hand pump during defib/cardioversion

HeartMate II

(Most common type in use today)

  1. Use: Bridge to transplant or destination therapy
  2. Flow type: Continuous
  3. Backup Method: No external method
  4. Battery: 14V Li-Ion - 10 hrs
  5. Defib/Cardioversion: No precautions
  6. Target INR: 1.8 to 2.5

Thoratec VAD (HeartMate III)

  1. Use: Bridge to Transplant
  2. Flow Type: Pulsatile
  3. Backup Method: No external method
  4. Battery: 12V lead acid gel battery - 7.2 Ah - up to 3 hrs
  5. Defib/Cardioversion: No precautions

HeartWare HVAD

  1. Use: Bridge to Transplant
  2. Anatomy: Designed to be implanted completely in pericardial space, no need for pump pocket formation
  3. Flow Type: Centrifugal pump
  4. Target INR: 2.0-3.0

Complications/Differential Diagnosis[3]

  • Bleeding - most common reason for ED visit, most common in first month after implant (frequency 42%[4])
  • Infection - driveline and pocket are most common sites[4]
  • Pump Thrombosis, estimated at 2-13%, average first thrombosis ~1 year after implant depending on device[7]
    • Low output state with falsely elevated pump flow estimates on controller
    • Diagnose with echo or cardiac CTA
    • Treatment with heparin and antiplatelet therapy
    • Consider tPA in life-threatening situations
    • Causes:
      • Mechanical - post-surgical ventricular debris, cardiac emboli, inflow cannula malposition
      • Inadequate anticoagulation and/or antiplatelet treatment
        • As optimal dosing and monitoring not well defined due to lack of clinical trials
        • Will occur despite rigid regimen and compliance of anticoagulation/antiplatelet
      • Prosthetic material inflammatory reaction with blood
      • Intrinsic endothelial activation in response to continuous flow-VAD
  • Arrhythmia - very common
    • Get labs to evaluate electrolytes and troponin
    • Treat atrial fibrillation as in any other patient
    • Treat ventricular arrhythmias with volume replacement and pharmacological or electrical cardioversion
      • Place pads anterior/posterior if going to cardiovert/defibrillate
  • "Suction event"
    • Pump pulls from an LV that hasn't filled
    • Causes:
      • Cannula malposition
      • Increased peripheral vascular resistance (hypertensive emergency)
      • Tamponade

Evaluation[3]

  • Assess perfusion and general state (mental status, skin temp/color, capillary refill, etc)
    • LVADs are preload dependant - if symptoms of hypoperfusion, give fluid blous
  • HR measured via ECG or auscultation (may be difficult secondary to pump noise)
  • Get 12-lead ECG on all LVAD patients
    • Demonstrates primary cardiac disease[8]
    • Generally, VAD does not influence underlying cardiac rhythm
  • Imaging:
    • Bedside echo if able, formal echo if available, with the following suggestive of thrombosis:
      • Cannula flow velocity > 2 m/s
      • More frequent opening of aortic valve than at baseline
      • Increasing LV internal dimension in diastole without manual speed changes
    • CT with contrast to look for thrombus, discuss with radiologist to protocol
  • Blood pressure measured with manual BP cuff and Doppler ultrasound - MAP is identified when constant flow is heard
  • Basic lab should be obtained on all LVAD patients
  • Cardiac labs - BNP, troponin
  • Include thrombolysis, coagulopathy labs
    • CBC
    • CMP, indirect bilirubin
    • PT/INT/PTT
    • LDH
    • Haptoglobin
    • Fibrinogen
    • UA, hematuria
    • Quantitative plasma free hemoglobin
    • Consider TEG
  • LDH elevation over 1,150 IU/L suggestive of pump thrombosis[9]
    • Approximate sensitivity of ~80% and specificity of 90%
    • Hemolysis within thrombosed pump releases LDH
  • Assess LVAD status
    • Auscultate for pump noise
    • Device parameters (found on controller)
      • Pump speed - varies by device - 2,000-10,000 RPM
      • Power - normal 4-6 Watts
      • Flow - normal 4-6 L/min
      • Pulsatility Index (PI) - normal 1-10
        • Measures magnitude of pulsatile flow provided by native cardiac contractions
        • Higher PI = less LVAD support
    • Clinical status more important than LVAD parameters

Management

  • Immediately contact hospital or patient's LVAD coordinator to help coordinate care
  • Check controller to ensure power light is on
    • Ensure humming sound of pump is auscultated over chest/abdomen
    • If pump not working, replace with patient's backup controller
    • Check all connections to power source, driveline, and controller are intact
    • Disconnect all connections after checking, and reconnect immediately
    • Inspect driveline for damages/defects
  • Assess battery, replace with backup battery
    • Patient should be positioned flat on stretcher before replacing battery
    • OR connect to hospital's power base unit or patient's power base unit if available
    • IF NONE OF ABOVE, contact VAD coordinator to find local LVAD patient in vicinity willing to transport extra batteries to ED
    • Take note that if battery is critically low, many devices will automatically lower speed, which can cause syncope or lightheadedness
  • Hemodynamic, supportive care[10]
    • Many LVAD patients fluid restrict too much due to their history, and LVADs are preload dependent
    • IVF crystalloid fluid bolus when indicated (low-flow indicator alarm)
    • MAP goal 70-90 mmHg
  • LVAD patients afterload sensitive
    • Address high BP emergently if thought to contribute to increased work of pump, which leads to thrombus and stroke
    • Beware of suction event complication, which requires IVF bolus and allowing the controller to sense this, slow pump speed and slowly bring up to fixed speed to allow for adequate ventricular filling
  • Take special care to not twist, bend, cut, or otherwise damage the driveline
  • First generation LVADs had pulsatile flow
    • Subsequent designs use continuous flow - patient will not have a palpable pulse
  • Patient will be on anticoagulation and antiplatelet therapy secondary to high risk of pump thrombus, CVA, and other thromboembolic events
  • VADs are ECG independant, unlike ICD (many patients with a VAD will also have an ICD in place)
    • ICD discharges are common, and frequently inappropriate (possibly secondary to LVAD interference)[8]
  • Ensure that patient or family bring in any additional batteries and charging elements as these will not be available in most hospital settings
  • Thrombosis, tPA in emergencies
    • Breadth of literature supporting is overall small
    • When patient not responding to continuous anticoagulation (heparin, argatroban drip)
    • AND when going directly to LVAD exchange or catheter-directed thrombolysis are not possibilities
    • Consider tPA if not contraindicated for survival and avoidance of needing LVAD exhange[11]
      • 5 mg IV bolus tPA
      • 3 mg/hr infusion in NS for 10 hours
      • 1 mg/hr for up to 48 hours, never exceeding 100 mg max total dosage
      • In single center study cited above, there was:
        • 70% that had hemolysis resolve and no need for LVAD exchange at 30 days
        • 95% survival at 30 days
        • 10% hemorrhagic stroke with no difference between tPA and control group
    • Alternative dosing, while plus/minus continuing heparin drip[12]
      • Initial dosing of 10 mg IV bolus
      • Followed by 1 mg/min for 20 min
      • Then 1 mg/hr for 24 hours
      • Monitor LDH levels and discontinue heparin drip when LDH acceptably lowered

Cardiac Arrest[3]

  • Unconscious, apneic, no evidence of LVAD function (auscultate for mechanical noise)
  • Immediately evaluate LVAD components and attach to reliable power source
    • Some first-generation LVADs have external hand pumps that can be used to provide circulation
  • Otherwise follow ACLS as in a normal patient
    • Patient should be intubated, given IV fluids and drugs, etc
  • Avoid chest compressions unless absolutely necessary - evaluate other causes of pump failure or lack of perfusion (e.g. pump thrombus) first
    • Compressions can potentially damage LVAD, disrupt its connection to the heart (risk of exsanguination), etc
    • Some studies available[13][14] indicate that CPR may not be as harmful as previously thought, or that abdominal compressions are an alternative[15] but further investigation needed
    • Use clinical judgement for initiation of compressions

Disposition

  • Immediately contact the patient's VAD coordinator
  • Almost all LVAD patient presenting to the ED will require admission or transfer to a site of expertise

See Also

External Links

References

  1. Mechem CC. Prehospital assessment and management of patients with ventricular-assist devices. Prehosp Emerg Care. 2013 Apr-Jun;17(2):223-9.
  2. Mancini D, Lietz K. Selection of cardiac transplantation candidates in 2010. Circulation. 2010;122(2):173-83.
  3. 3.0 3.1 3.2 Partyka C, Taylor B. Review article: ventricular assist devices in the emergency department. Emerg Med Australas. 2014 Apr;26(2):104-12.
  4. 4.0 4.1 Rose EA, Gelijns AC, Moskowitz AJ et al. Long-term use of a left ventricular assist device for end-stage heart failure. N. Engl. J. Med. 2001; 345: 1435–1443.
  5. Suarez J., Patel C.B., Felker G.M., Becker R., Hernandez A.F., Rogers J.G. Mechanisms of bleeding and approach to patients with axial-flow left ventricular assist devices. Circ Heart Fail. 2011;4:770–784.
  6. Jennings, D, et al. Safety of Anticoagulation Reversal in Patients Supported with Continuous-Flow Left Ventricular Assist Devices. ASAIO Journal. July 2014. 60:381–384
  7. Nair N et al. Thrombolytics in VAD management — A single-center experience. Int J Cardiol Heart Vasc. 2016 Jun; 11: 49–54.
  8. 8.0 8.1 Pistono M, Corrà U, Gnemmi M, Imparato A, Temporelli PL, Tarro Genta F, Giannuzzi P. How to face emergencies in heart failure patients with ventricular assist device. Int J Cardiol. 2013 Oct 15;168(6):5143-8
  9. Zoler ML. Cardiology News. STS: Lactate dehydrogenase of 1,150 IU/L flags LVAD thrombosis. https://www.mdedge.com/ecardiologynews/article/106621/heart-failure/sts-lactate-dehydrogenase-1150-iu/l-flags-lvad. Published Feb 19, 2016.
  10. Troubleshooting the Left Ventricular Assist Device. Emergency Medicine. 2016 February;48(2):58-63.
  11. Nair N et al. Thrombolytics in VAD management — A single-center experience. Int J Cardiol Heart Vasc. 2016 Jun; 11: 49–54.
  12. Webber BT et al. Intravenous thrombolytic therapy for patients with ventricular assist device thrombosis: An attempt to avoid reoperation. Ann Card Anaesth. 2016 Jan-Mar; 19(1): 192–196.
  13. Shinar Z, Bellezzo J, Stahovich M, Cheskes S, Chillcott S, Dembitsky W. Chest compressions may be safe in arresting patients with left ventricular assist devices (LVADs). Resuscitation. 2014 May;85(5):702-4.
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