Lactic acidosis

Background

• Most common cause of metabolic acidosis in hospitalized patients
• Type A
  • Impaired tissue oxygenation
    • Hypovolemia
    • Cardiac failure
    • Sepsis

• Type B
  • No impaired tissue oxygenation
    • Alcoholism
      • Lactate utilization is impaired 2/2 impaired hepatic gluconeogenesis
    • Metformin