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General
- Type: NSAID
- Dosage Forms: 15 mg/mL, 30 mg/mL injection
- Common Trade Names: Toradol
Adult Dosing
- Acute pain:
- IM: 30-60 mg x 1 or 30 mg q6h
- IV: 30 mg x 1, then 15-30 mg q6h
- Black box warning against tx for > 5 days
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Enters breast milk, use caution
- Elderly (> 65 yo): Decrease dose by 50%
- Renal Dosing
- Mild-Moderate impairment: Decrease dose by 50%
- Severe impairment or HD: Contraindicated
- Hepatic Dosing: No dose change, but may increase LFTs
Contraindications
- Allergy to class/drug
- Active or prior PUD, recent GIB
- Severe renal disease or HD
- Bleeding diathesis
Adverse Reactions
Serious
- Bleeding, MI, CVA, GI bleed/perforation, Hyperkalemia
Common
Pharmacology
- Onset: 20-30 minutes
- Peak: 2-3 hours
- Duration: 4-6 hours
- Half-life: 2-6 hours, up to 19 hours in renal dz
- Metabolism: Hepatic
- Excretion: Renal
- Mechanism of Action: NSAID, Reversible COX-1/2 inhibitor
See Also
Sources
