Difference between revisions of "Ketorolac"

(Special Populations)
(Pharmacology)
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==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Onset: 20-30 minutes
*Metabolism:  
+
*Peak: 2-3 hours
*Excretion:  
+
*Duration: 4-6 hours
*Mechanism of Action:
+
*Half-life: 2-6 hours, up to 19 hours in renal dz
 +
*Metabolism: Hepatic
 +
*Excretion: Renal
 +
*Mechanism of Action: NSAID, Reversible COX-1/2 inhibitor
  
 
==See Also==
 
==See Also==

Revision as of 01:12, 23 May 2015

General

  • Type: NSAID
  • Dosage Forms: 15 mg/mL, 30 mg/mL injection
  • Common Trade Names: Toradol

Adult Dosing

  • Acute pain:
    • IM: 30-60 mg x 1 or 30 mg q6h
    • IV: 30 mg x 1, then 15-30 mg q6h
    • Black box warning against tx for > 5 days

Pediatric Dosing

  • N/A

Special Populations

  • Pregnancy Rating: C
  • Lactation: Enters breast milk, use caution
  • Elderly (> 65 yo): Decrease dose by 50%
  • Renal Dosing
    • Mild-Moderate impairment: Decrease dose by 50%
    • Severe impairment or HD: Contraindicated
  • Hepatic Dosing: No dose change, but may increase LFTs

Contraindications

  • Allergy to class/drug
  • Active or prior PUD, recent GIB
  • Severe renal disease or HD
  • Bleeding diathesis

Adverse Reactions

Serious

  • Bleeding, MI, CVA, GI bleed/perforation, Hyperkalemia

Common

  • Dispepsia, nausea, HA

Pharmacology

  • Onset: 20-30 minutes
  • Peak: 2-3 hours
  • Duration: 4-6 hours
  • Half-life: 2-6 hours, up to 19 hours in renal dz
  • Metabolism: Hepatic
  • Excretion: Renal
  • Mechanism of Action: NSAID, Reversible COX-1/2 inhibitor

See Also

Sources