Ipratropium: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: Anticholinergic Agent | ||
*Dosage Forms: | *Dosage Forms: Oral inhalation | ||
*Common Trade Names: Atrovent | *Common Trade Names: Atrovent | ||
==Adult Dosing== | ==Adult Dosing== | ||
[[Asthma]]: 0.5mg Nebulized q20min, up to 3 doses<br /> | |||
[[COPD]]: 0.5mg Nebulized q20mins, up to 3 doses | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
[[Asthma]] | |||
*Children ≤5 years: 0.25mg Neb q20mins, up to 3 doses | |||
*Children ≤12 years: 0.25-0.5mg Neb q20mins, up to 3 doses | |||
*Children >12 years: Refer to adult dosing | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | ||
*Lactation: | *[[Lactation risk categories]]: L3 | ||
*Renal Dosing | *Renal Dosing - none | ||
*Hepatic Dosing - none | |||
*Hepatic Dosing | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to | *Allergy to anticholenergics (Atropine, Ipatropium) | ||
*Not to be used as sole rescue agent in acute exacerbation | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Death | |||
===Common=== | ===Common=== | ||
*Urinary retention | |||
*Increased intraocular pressure | |||
*Bitter taste in mouth | |||
*Dry throat/Cough | |||
*Nasal dryness | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 2-5hrs | ||
*Metabolism: | *Metabolism: Possible ester hydrolysis | ||
*Excretion: | *Excretion: Fecal and Renal | ||
*Mechanism of Action: | *Mechanism of Action: Cholinergic antagonist of acetylcholine at the cholinergic receptors, causing dilatation of bronchial smooth muscle and decreased serous and seromucous glands secretion. | ||
==See Also== | ==See Also== | ||
==References== | |||
<references/> | <references/> | ||
[[Category: | |||
[[Category:Pharmacology]] | |||
[[Category:Pulmonology]] | |||
Latest revision as of 20:50, 22 September 2019
General
- Type: Anticholinergic Agent
- Dosage Forms: Oral inhalation
- Common Trade Names: Atrovent
Adult Dosing
Asthma: 0.5mg Nebulized q20min, up to 3 doses
COPD: 0.5mg Nebulized q20mins, up to 3 doses
Pediatric Dosing
- Children ≤5 years: 0.25mg Neb q20mins, up to 3 doses
- Children ≤12 years: 0.25-0.5mg Neb q20mins, up to 3 doses
- Children >12 years: Refer to adult dosing
Special Populations
- Pregnancy Rating: B
- Lactation risk categories: L3
- Renal Dosing - none
- Hepatic Dosing - none
Contraindications
- Allergy to anticholenergics (Atropine, Ipatropium)
- Not to be used as sole rescue agent in acute exacerbation
Adverse Reactions
Serious
- Death
Common
- Urinary retention
- Increased intraocular pressure
- Bitter taste in mouth
- Dry throat/Cough
- Nasal dryness
Pharmacology
- Half-life: 2-5hrs
- Metabolism: Possible ester hydrolysis
- Excretion: Fecal and Renal
- Mechanism of Action: Cholinergic antagonist of acetylcholine at the cholinergic receptors, causing dilatation of bronchial smooth muscle and decreased serous and seromucous glands secretion.