Iodoquinol

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Administration

  • Type: Amebicide
  • Routes of Administration: Oral
  • Common Trade Names: Aloquin; Yodoxin

Adult Dosing

  • 650mg 3 times daily after meals for 20 days
    • Not to exceed 1.95 g daily

Pediatric Dosing

  • Children: 30-40mg/kg daily (maximum: 650mg per dose) in 3 divided doses for 20 days
    • Not to exceed 1.95 g daily

Special Populations

  • Limited data on use during pregnancy

Renal Dosing

  • No adjustments noted by manufacturer

Hepatic Dosing

  • No adjustments noted by manufacturer

Contraindications

  • Allergy to class/drug, hypersensitivity to iodine and/or 8-hydroxyquinolones
  • Concerns with optic neuritis
  • Concerns with peripheral neuropathy
  • Hepatic impairment
  • Renal impairment
  • Chronic diarrhea, especially in children

Adverse Reactions

Serious

  • Peripheral neuropathy, Long-term (high-dose)
  • Optic atrophy, Long-term (high-dose)
  • Optic neuritis, Long-term (high-dose)

Common

  • Nausea/vomiting, diarrhea, cramps
  • Fever/chills
  • Pruritus, urticaria
  • Headache, dizziness

Pharmacology

  • Half-life:
  • Metabolism: Liver
  • Excretion: Feces, urine

Mechanism of Action

  • Contact amebicide that works in the lumen of the intestine (unknown mechanism)

Comments

See Also

References

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