Difference between revisions of "Insulin"

 
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{| width="342" border="1"
+
==Types==
| Type
+
{| class="wikitable"  
| Onset of action (h)
 
| Peak action
 
| Effective duration
 
| Max duration
 
 
|-
 
|-
| colspan="5" | RAPID ACTING
+
| <u>'''Type'''</u>
 +
| <u>'''Onset of action (h)'''</u>
 +
| <u>'''Peak action'''</u>
 +
| <u>'''Effective duration'''</u>
 +
| <u>'''Max duration'''</u>
 
|-
 
|-
|
+
| colspan="5" | '''RAPID ACTING'''
 +
|-
 +
|  
 
Lispro
 
Lispro
  
 
(humalog)
 
(humalog)
| 0.25-0.5 <br />
+
 
 +
| 0.25-0.5<br/>
 
| 0.5-1.25
 
| 0.5-1.25
 
| 3-4
 
| 3-4
 
| 4-6
 
| 4-6
 
|-
 
|-
|
+
|  
 
Aspart
 
Aspart
  
 
(novolog)
 
(novolog)
| 0.25-0.5<br />
+
 
 +
| 0.25-0.5<br/>
 
| 0.5-1.25
 
| 0.5-1.25
 
| 3-4
 
| 3-4
 
| 4-6
 
| 4-6
 
|-
 
|-
|
+
|  
 
Glulisine
 
Glulisine
  
 
(apidra)
 
(apidra)
 +
 
| 0.25-0.5
 
| 0.25-0.5
| 0.25-1.25 <br />
+
| 0.25-1.25<br/>
 
| 3-4
 
| 3-4
 
| 4-6
 
| 4-6
 
|-
 
|-
| colspan="5" | SHORT ACTING<br />
+
| colspan="5" | '''SHORT ACTING<br/>'''
 
|-
 
|-
 
| Regular
 
| Regular
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| 6-8
 
| 6-8
 
|-
 
|-
| colspan="5" | INTERMEDIATE ACTING
+
| colspan="5" | '''INTERMEDIATE ACTING'''
 
|-
 
|-
 
| NPH
 
| NPH
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| 14-18
 
| 14-18
 
|-
 
|-
| colspan="5" | LONG ACTING
+
| colspan="5" | '''LONG ACTING'''
 
|-
 
|-
|
+
|  
 
glargine
 
glargine
  
 
(Lantus)
 
(Lantus)
 +
 
| 3-4
 
| 3-4
 
| 8-16
 
| 8-16
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| 20-24
 
| 20-24
 
|-
 
|-
|
+
|  
 
detemir
 
detemir
  
 
(Levemir)
 
(Levemir)
 +
 
| 3-4
 
| 3-4
 
| 6-8
 
| 6-8
 
| 14
 
| 14
 
| ~20
 
| ~20
|}  
+
|}
  
 +
[[File:Insulin.jpg|thumbnail]]
  
Type Onset of action (h) Peak action Effective duration Max duration
+
{{Common Anti-hyperglycemic Drugs and Pharmacology}}
RAPID ACTING
 
Lispro
 
  
(humalog)
+
==Insulin Sliding Scale==
 
+
*Dosing depends on the patient's level of insulin resistance.  
0.25-0.5 0.5-1.25 3-4 4-6
+
*The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL
Aspart
 
 
 
(novolog)
 
 
 
0.25-0.5 0.5-1.25 3-4 4-6
 
Glulisine
 
 
 
(apidra)
 
 
 
0.25-0.5 0.25-1.25  3-4 4-6
 
SHORT ACTING
 
Regular 0.5-1 2-3 3-6 6-8
 
INTERMEDIATE ACTING
 
NPH 2-4 6-10 10-16 14-18
 
LONG ACTING
 
glargine
 
 
 
(Lantus)
 
 
 
3-4 8-16 18-20 20-24
 
detemir
 
 
 
(Levemir)
 
  
3-4 6-8 14 ~20
+
===Low Dose (Renal Insufficiency)===
+
*BG 150-199: 1 unit bolus Insulin
 +
*BG 200-249: 2 units bolus Insulin
 +
*BG 250-299: 3 units bolus Insulin
 +
*BG 300-349: 4 units bolus Insulin
 +
*BG Over 350: 5 units bolus Insulin
  
 +
===Medium Dose (Standard)===
 +
*BG 150-199: 1 unit bolus Insulin
 +
*BG 200-249: 3 units bolus Insulin
 +
*BG 250-299: 5 units bolus Insulin
 +
*BG 300-349: 7 units bolus Insulin
 +
*BG Over 350: 8 units bolus Insulin
  
 +
===High Dose (Severely Insulin Resistant)===
 +
*BG 150-199: 2 unit bolus Insulin
 +
*BG 200-249: 4 units bolus Insulin
 +
*BG 250-299: 7 units bolus Insulin
 +
*BG 300-349: 10 units bolus Insulin
 +
*BG Over 350: 12 units bolus Insulin
  
 +
==See Also==
 +
*[[Diabetes (Main)]]
  
[[Category:Drugs]]
+
[[Category:Pharmacology]]
 +
[[Category:Endocrinology]]

Latest revision as of 07:47, 9 June 2016

Types

Type Onset of action (h) Peak action Effective duration Max duration
RAPID ACTING

Lispro

(humalog)

0.25-0.5
0.5-1.25 3-4 4-6

Aspart

(novolog)

0.25-0.5
0.5-1.25 3-4 4-6

Glulisine

(apidra)

0.25-0.5 0.25-1.25
3-4 4-6
SHORT ACTING
Regular 0.5-1 2-3 3-6 6-8
INTERMEDIATE ACTING
NPH 2-4 6-10 10-16 14-18
LONG ACTING

glargine

(Lantus)

3-4 8-16 18-20 20-24

detemir

(Levemir)

3-4 6-8 14 ~20
Insulin.jpg

Common Anti-hyperglycemic Drugs and Pharmacology

Drug Pharmacology
Onset Peak Duration
Rapid-acting insulin

  • Aspart (Novolog)
  • Lispro (Humalog)
15-30min 1-2h 3-5h
Short-acting insulin

  • Regular
30-60min 2-4h 6-10h
Intermediate-acting insulin

  • NPH (Humulin, Novolin)
1-3h 4-12h 18-24h
Long-acting insulin

  • Glargine (Lantus)
2-4h None 24h
Sulfonylurea

  • Glimepiride
  • Glipizide (Glucotrol)
  • Glyburide (Glycron, Micronase)
2-6h 12-24h

Insulin Sliding Scale

  • Dosing depends on the patient's level of insulin resistance.
  • The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL

Low Dose (Renal Insufficiency)

  • BG 150-199: 1 unit bolus Insulin
  • BG 200-249: 2 units bolus Insulin
  • BG 250-299: 3 units bolus Insulin
  • BG 300-349: 4 units bolus Insulin
  • BG Over 350: 5 units bolus Insulin

Medium Dose (Standard)

  • BG 150-199: 1 unit bolus Insulin
  • BG 200-249: 3 units bolus Insulin
  • BG 250-299: 5 units bolus Insulin
  • BG 300-349: 7 units bolus Insulin
  • BG Over 350: 8 units bolus Insulin

High Dose (Severely Insulin Resistant)

  • BG 150-199: 2 unit bolus Insulin
  • BG 200-249: 4 units bolus Insulin
  • BG 250-299: 7 units bolus Insulin
  • BG 300-349: 10 units bolus Insulin
  • BG Over 350: 12 units bolus Insulin

See Also