Hyperthyroidism: Difference between revisions
No edit summary |
|||
(32 intermediate revisions by 10 users not shown) | |||
Line 1: | Line 1: | ||
==Background== | ==Background== | ||
*Hyperthyroidism: Excess circulating hormone resulting from thyroid gland hyperfunction | *Hyperthyroidism: Excess circulating hormone resulting from thyroid gland hyperfunction | ||
*Thyrotoxicosis: Excess circulating thyroid hormone originating from any cause | *[[Thyrotoxicosis]]: Excess circulating thyroid hormone originating from any cause | ||
==Causes== | ===Causes=== | ||
'''Primary Hyperthyroidism''' | |||
*Graves disease (toxic diffuse goitre) | |||
**Most common cause of hyperthyroidism (85% of cases) | |||
**Autoantibodies bind to TSH receptor and stimulate thyroid hormone production and release <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
**Associated with diffuse goitre, ophthalmopathy, local dermopathy | |||
**Strong genetic relationship, often found with other autoimmune disorders <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
*Toxic multinodular goitre | |||
**2nd most common cause | |||
**Multiple autonomously functioning nodules <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
**Milder, more gradual disease than Graves' hyperthyroidism | |||
*Toxic nodular (adenoma) goitre | |||
**Single hyperfunctioning nodule | |||
**Similar presentation to multinodular goitre, but less common <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
'''Secondary Hyperthyroidism''' | |||
*Thyrotropin-secreting pituitary adenoma | |||
*Thyroiditis | |||
**Hashimoto thyroiditis | |||
***Autoimmune disorder | |||
***Thyroid antibodies and lymphocytic infiltration <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
***Painless goitre | |||
***Initially gland is overactive (hyperthyroidism state) followed by hypothyroidism | |||
**Subacute painful thyroiditis (de Quervain thyroiditis)<ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
***May be caused by viral infection | |||
***Viral prodrome followed by anterior neck pain | |||
***Tender thyroid (palpation, head movement, swallowing) | |||
***50% have symptoms of hyperthyroid lasting 3 - 6 weeks | |||
***1/3 have hypothyroidism for up to 6 months | |||
**Subacute painless thyroiditis <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
***Small, non-tender goitre | |||
***Mild symptoms | |||
***Autoimmune | |||
**Postpartum thyroiditis <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
***3 phases: | |||
****Thyrotoxic phase 2 -6 months postpartum (20-30% have only this phase) | |||
****Hypothyroid phase lasting 2 -3 months (but may be permanent) (40% have this phase only) | |||
****Euthyroid phase within first postpartum year | |||
***Some women develop permanent hypothyroidism | |||
***70% recurrence in subsequent pregnancies | |||
**Suppurative thyroiditis <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
***Rare | |||
***Life-threatening | |||
***Infection usually bacterial, but can be parasitic, mycobacterial, or fungal | |||
***Usually have pre-existing thyroid disorder and immune compromise | |||
**Radiation thyroiditis | |||
'''Other causes:''' | |||
*Apathetic thyrotoxicosis (elderly, masking comorbidities) | |||
*Metastatic thyroid cancer | |||
*Iodine-induced thyrotoxicosis | |||
*[[Amiodarone]]-induced thyroiditis <ref>Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders </ref> | |||
**Possible mechanisms: | |||
***Drug-induced destructive thyroiditis | |||
***Hyperthyroidism caused by iodine load (amiodarone contains a large amount of iodine) | |||
**Drug-induced thyroiditis may also occur with interleukin-2, [[Interferon-α]], [[lithium]], tyrosine kinase inhibitors, HAART | |||
*[[Molar pregnancy]] | |||
{{Thyroid gen background}} | |||
==Clinical Features== | ==Clinical Features== | ||
[[File:PMC5384127 TJO-47-94-g6.png|thumb|Bilateral infiltrative thyroid-associated exophthalmos]] | |||
[[File:PMC3742527 OL-06-01-0144-g00.png|thumb|Enlarged and homogeneous thyroid.]] | |||
[[File:PMC3371544 IJD-57-247-g002.png|thumb|"Plummer's nail" demonstrating onycholysis (separation of the nail from the nail bed). Abnormal nail findings occurs in about 5% of hyperthyroid patients.]] | |||
'''Constitutional signs:''' | |||
*[[Lethargy]] | |||
*Diaphoresis | |||
*[[Weakness]] | |||
*[[Fever]] | |||
*Heat intolerance | |||
*Weight loss | |||
'''Neuropsychiatric:''' | |||
*Emotional lability | |||
*Fine [[tremor]] | |||
*[[Anxiety]] | |||
*Muscle wasting | |||
*[[Confusion]] | |||
*Hyperreflexia | |||
*[[Coma]] | |||
*[[Thyrotoxic periodic paralysis|Periodic paralysis]] | |||
*Psychosis | |||
'''Ophthalmologic:''' | |||
*[[Diplopia]] | |||
*Lid lag | |||
*Eye irritation | |||
*Exophthalmos | |||
*Ophthalmoplegia | |||
'''Endocrine:''' | |||
*Neck fullness/tenderness (thyroid gland) | |||
'''Cardiorespiratory:''' | |||
*[[Dyspnea]] | |||
*Widened pulse pressure | |||
*[[Palpitations]] | |||
*Systolic [[hypertension]] | |||
*[[Chest pain]] | |||
*[[Sinus tachycardia]] | |||
*[[Atrial fibrillation]] | |||
**Occurs in 10-20% of patients and can revert to sinus rhythm when hyperthyroidism treated | |||
*[[Atrial flutter]] | |||
*[[CHF]] | |||
'''GI:''' | |||
*[[Diarrhea]] | |||
*Hyperactive bowel sounds | |||
'''Reproductive:''' | |||
*Oligomenorrhea | |||
*Gynecomastia | |||
*Telangiectasia | |||
'''Gynecologic:''' | |||
*Menorrhagia | |||
*Sparse pubic hair | |||
'''Hematologic:''' | |||
*[[Anemia]] | |||
*[[Leukocytosis]] | |||
'''Dermatologic:''' | |||
*[[alopecia|Hair loss]] | |||
*Pretibial myxedema | |||
*Warm, moist skin | |||
*Palmar erythema | |||
*Onycholysis | |||
'''Apathetic hyperthyroidism:''' (elderly patients)<ref>Rehman SU et al. Thyroid Disorders in Elderly Patients. South Med J. 2005;98(5):543-549.</ref> | |||
*Placid apathetic facies | |||
*Depression | |||
*Lethargy | |||
*Muscular weakness and wasting | |||
*Excessive weight loss | |||
*Cardiac [[dysrhythmias]] | |||
*Absent or small goiter | |||
*Absence of ocular symptoms | |||
*[[Agitation]] and [[confusion]] | |||
==Differential Diagnosis== | |||
===Tachycardia=== | |||
*[[Anemia]] | |||
*[[Dehydration]] | |||
*[[Fever]] | |||
*[[Infection]], [[Sepsis]] | |||
*[[Anion gap acidosis]] | |||
*[[Hyperthyroid]] | |||
*[[Arrhythmia]] | |||
*[[PE]] | |||
*[[CHF]] | |||
*[[MI]] | |||
*[[Tamponade]] | |||
*[[Myocardial contusion]] | |||
*Cardiac [[valvular emergencies|valvular disease]] | |||
*Hyper/[[hypoglycemia]] | |||
*[[drug overdose|Drug intoxication]] | |||
*Drug withdrawal | |||
*Toxicity | |||
**[[salicylate toxicity|ASA]] | |||
**[[TCA toxicity|TCA]] | |||
**[[Anticholinergic toxicity|Anticholinergic]] | |||
**[[Theophylline toxicity|Theophylline]] | |||
*Pain | |||
*Psych (anger, fear) | |||
{{Palpitations DDX}} | |||
==Evaluation== | |||
===Workup=== | |||
*TSH (↓) | |||
*Free T4 (↑) | |||
*Free T3 (↑) | |||
===Diagnosis=== | |||
[[File:thyroid studies.JPG|px200]] | |||
==Management== | |||
*If asymptomatic or mild symptoms, no treatment required in ED | |||
*If symptomatic, consider [[Thyroid storm]] | |||
==Disposition== | |||
*If asymptomatic or no thyroid storm, discharge with outpatient follow-up. | |||
*Admit for significant symptoms or thyroid storm. | |||
==See Also== | ==See Also== | ||
[[Thyroid | *[[Thyroid storm]] | ||
[[Thyroid ( | *[[Thyroid (Main)]] | ||
== | ==References== | ||
<references/> | |||
[[Category: | [[Category:Endocrinology]] |
Latest revision as of 15:41, 1 November 2023
Background
- Hyperthyroidism: Excess circulating hormone resulting from thyroid gland hyperfunction
- Thyrotoxicosis: Excess circulating thyroid hormone originating from any cause
Causes
Primary Hyperthyroidism
- Graves disease (toxic diffuse goitre)
- Toxic multinodular goitre
- 2nd most common cause
- Multiple autonomously functioning nodules [3]
- Milder, more gradual disease than Graves' hyperthyroidism
- Toxic nodular (adenoma) goitre
- Single hyperfunctioning nodule
- Similar presentation to multinodular goitre, but less common [4]
Secondary Hyperthyroidism
- Thyrotropin-secreting pituitary adenoma
- Thyroiditis
- Hashimoto thyroiditis
- Autoimmune disorder
- Thyroid antibodies and lymphocytic infiltration [5]
- Painless goitre
- Initially gland is overactive (hyperthyroidism state) followed by hypothyroidism
- Subacute painful thyroiditis (de Quervain thyroiditis)[6]
- May be caused by viral infection
- Viral prodrome followed by anterior neck pain
- Tender thyroid (palpation, head movement, swallowing)
- 50% have symptoms of hyperthyroid lasting 3 - 6 weeks
- 1/3 have hypothyroidism for up to 6 months
- Subacute painless thyroiditis [7]
- Small, non-tender goitre
- Mild symptoms
- Autoimmune
- Postpartum thyroiditis [8]
- 3 phases:
- Thyrotoxic phase 2 -6 months postpartum (20-30% have only this phase)
- Hypothyroid phase lasting 2 -3 months (but may be permanent) (40% have this phase only)
- Euthyroid phase within first postpartum year
- Some women develop permanent hypothyroidism
- 70% recurrence in subsequent pregnancies
- 3 phases:
- Suppurative thyroiditis [9]
- Rare
- Life-threatening
- Infection usually bacterial, but can be parasitic, mycobacterial, or fungal
- Usually have pre-existing thyroid disorder and immune compromise
- Radiation thyroiditis
- Hashimoto thyroiditis
Other causes:
- Apathetic thyrotoxicosis (elderly, masking comorbidities)
- Metastatic thyroid cancer
- Iodine-induced thyrotoxicosis
- Amiodarone-induced thyroiditis [10]
- Possible mechanisms:
- Drug-induced destructive thyroiditis
- Hyperthyroidism caused by iodine load (amiodarone contains a large amount of iodine)
- Drug-induced thyroiditis may also occur with interleukin-2, Interferon-α, lithium, tyrosine kinase inhibitors, HAART
- Possible mechanisms:
- Molar pregnancy
Spectrum of Thyroid Disease
- Myxedema coma << hypothyroidism < euthyroid > hyperthyroidism >> thyroid storm
Clinical Features
Constitutional signs:
Neuropsychiatric:
- Emotional lability
- Fine tremor
- Anxiety
- Muscle wasting
- Confusion
- Hyperreflexia
- Coma
- Periodic paralysis
- Psychosis
Ophthalmologic:
- Diplopia
- Lid lag
- Eye irritation
- Exophthalmos
- Ophthalmoplegia
Endocrine:
- Neck fullness/tenderness (thyroid gland)
Cardiorespiratory:
- Dyspnea
- Widened pulse pressure
- Palpitations
- Systolic hypertension
- Chest pain
- Sinus tachycardia
- Atrial fibrillation
- Occurs in 10-20% of patients and can revert to sinus rhythm when hyperthyroidism treated
- Atrial flutter
- CHF
GI:
- Diarrhea
- Hyperactive bowel sounds
Reproductive:
- Oligomenorrhea
- Gynecomastia
- Telangiectasia
Gynecologic:
- Menorrhagia
- Sparse pubic hair
Hematologic:
Dermatologic:
- Hair loss
- Pretibial myxedema
- Warm, moist skin
- Palmar erythema
- Onycholysis
Apathetic hyperthyroidism: (elderly patients)[11]
- Placid apathetic facies
- Depression
- Lethargy
- Muscular weakness and wasting
- Excessive weight loss
- Cardiac dysrhythmias
- Absent or small goiter
- Absence of ocular symptoms
- Agitation and confusion
Differential Diagnosis
Tachycardia
- Anemia
- Dehydration
- Fever
- Infection, Sepsis
- Anion gap acidosis
- Hyperthyroid
- Arrhythmia
- PE
- CHF
- MI
- Tamponade
- Myocardial contusion
- Cardiac valvular disease
- Hyper/hypoglycemia
- Drug intoxication
- Drug withdrawal
- Toxicity
- Pain
- Psych (anger, fear)
Palpitations
- Arrhythmias:
- Non-arrhythmic cardiac causes:
- Psychiatric causes:
- Drugs and Medications:
- Alcohol
- Caffeine
- Drugs of abuse (e.g. cocaine)
- Medications (e.g. digoxin, theophylline)
- Tobacco
- Misc
Evaluation
Workup
- TSH (↓)
- Free T4 (↑)
- Free T3 (↑)
Diagnosis
Management
- If asymptomatic or mild symptoms, no treatment required in ED
- If symptomatic, consider Thyroid storm
Disposition
- If asymptomatic or no thyroid storm, discharge with outpatient follow-up.
- Admit for significant symptoms or thyroid storm.
See Also
References
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Thiessen, M. (2018). Thyroid and Adrenal Disorders. Rosen's emergency medicine: Concepts and clinical practice (9th ed.). Philadelphia, PA: Elsevier/Saunders
- ↑ Rehman SU et al. Thyroid Disorders in Elderly Patients. South Med J. 2005;98(5):543-549.